Table 4. Final prediction model.
TC=total cholesterol, DM=diabetes mellitus, PTB=preterm birth, BMI=body mass index, AFP=alpha fetoprotein, MoM=multiples of the median. The betas are the coefficients resulting from the logistic regression fit. Some variables that remained as significant predictors had missing values and thus those individuals are not included in the model. For the entire cohort there were missing values in TBs for BMI (1), Inhibin A (176) and maternal degree (2). There were also missing values in PTBs for maternal degree (3) and inhibin A (8). The odds ratios (OR) for the cholesterol variables are expressed using their standard deviation as the unit of change; 30.9 mg/dL for 1st trimester TC and 18.5 for TC change.
| Explanatory Variable | Beta | OR (95% CI) | P |
|---|---|---|---|
| Entire Cohort | |||
| Intercept | −4.32 | ||
| TC 1st Trimester (mg/dL) | 0.005 | 1.17 (1.01,1.36) | 0.032 |
| TC Change 1st to 2nd Trimester (mg/dL) |
−0.008 | 0.87 (0.74,1.01) | 0.072 |
| Maternal Degree | −0.411 | 0.66 (0.48,0.91) | 0.012 |
| Pre-pregnancy DM | 1.140 | 3.13 (1.38,6.51) | 0.004 |
| Previous PTB | 1.440 | 4.25 (2.34,7.44) | <0.001 |
| Previous Live Birth | −0.494 | 0.61 (0.44,0.84) | 0.003 |
| 1st Trimester BMI<18.5 | 1.058 | 2.88 (1.31,5.77) | 0.005 |
| 1st Trimester BMI>40 | 0.375 | 1.46 (0.84,2.41) | 0.161 |
| AFP (MoM) | 0.880 | 2.41 (1.71,3.40) | <0.001 |
| Inhibin A (MoM) | 0.308 | 1.36 (1.11,1.68) | 0.004 |
| No Previous PTB | |||
| TC 1st Trimester (mg/dL) | 1.17 (1.00,1.38) | 0.049 | |
| TC Change 1st to 2nd Trimester (mg/dL) |
0.85 (0.72,0.99) | 0.044 | |
| Maternal Degree | 0.69 (0.49,0.95) | 0.026 | |
| Pre-pregnancy DM | 3.36 (1.43,7.17) | 0.003 | |
| Previous Live Birth | 0.61 (0.44,0.84) | 0.003 | |
| 1st Trimester BMI<18.5 | 2.92 (1.33,5.84) | 0.004 | |
| 1st Trimester BMI>40 | 1.33 (0.73,2.29) | 0.322 | |
| AFP (MoM) | 2.24 (1.57,3.20) | <0.001 | |
| Inhibin A (MoM) | 1.33 (1.07,1.67) | 0.011 | |