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. 2013 Aug 21;13:392. doi: 10.1186/1471-2407-13-392

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Copyright © 2013 Hirakawa et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overall survival of patients based on IGF1R and IGFBP3 expression. The survival curve shows the Kaplan-Meier overall survival curves in relation to the IGF1R and IGFBP3 levels in patients with pancreatic cancer. A statistically significant difference in survival was observed between patients with IGF1R-positive and IGF1R-negative tumors (p = 0.018). The prognosis of patients with IGF1R-positive and IGFBP3-negative patients showed a significant correlation with overall survival (p < 0.001). IGFBP3 expression alone tended to be associated with overall survival (p = 0.079). The co-expression of IGF1R-negative and IGFBP3-positive PDAC was not associated with overall survival (p = 0.218).