Table 2. FGF21 treatment-induced gene expression changes of adipose tissue transcripts encoding potential secreted proteins.
| Probeset ID | Gene Symbol | Entrez Gene ID | WT Chow. PEG30-FGF21 Q108, 2.5 mg/kg, 2d / Vehicle Treatment |
Validation Study. IWAT. Fold Change |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IWAT | EWAT | RPWAT | n=5 | n=5 | n=5 | ||||||
| Fold Change | ANOVA p | Fold Change | ANOVA p | Fold Change | ANOVA p | 0.25 mg/kg | 0.75 mg/kg | 2.5 mg/kg | |||
| merck-AK053042_at | Nav3 | 260315 | 2.2 | 0.008 | 2.2 | 0.000 | 2.2 | 0.000 | 3.9 | 2 | 3.1 |
| merck-NM_177274_at | Negr1 | 320840 | 2.1 | 0.001 | 1.6 | 0.054 | 1.5 | 0.039 | 3.5 | 1.3 | 2 |
| merck-NM_001024698_at | Cpa2 | 232680 | 2.0 | 0.225 | 2.3 | 0.016 | 3.7 | 0.026 | |||
| merck-NM_010171_at | F3 | 14066 | 1.7 | 0.023 | 1.7 | 0.005 | 1.9 | 0.001 | |||
| merck-AF128205_a_at | Ccl11 | 20292 | 1.6 | 0.086 | 1.0 | 0.986 | 1.6 | 0.020 | |||
| merck-NM_010512_at | Igf1 | 16000 | -1.1 | 0.035 | -1.2 | 0.036 | -1.2 | 0.017 | |||
| merck-NM_010517_s_at | Igfbp4 | 16010 | -1.3 | 0.000 | -1.3 | 0.000 | -1.2 | 0.004 | |||
| merck-NM_008520_at | Ltbp3 | 16998 | -1.4 | 0.008 | -1.4 | 0.000 | -1.5 | 0.000 | |||
| merck-NM_008489_at | Lbp | 16803 | -1.4 | 0.001 | -1.5 | 0.003 | -1.3 | 0.116 | |||
| merck-ENSMUST00000015791_at | Lama5 | 16776 | -1.5 | 0.001 | -1.2 | 0.038 | -1.3 | 0.019 | |||
| merck-NM_007925_at | Eln | 13717 | -1.5 | 0.003 | -1.1 | 0.087 | -1.2 | 0.083 | |||
| merck-BB213274_s_at | Kitl | 17311 | -1.7 | 0.001 | -1.2 | 0.036 | -1.4 | 0.007 | |||
| merck-NM_030565_at | Fam20c | 80752 | -1.7 | 0.001 | -2.1 | 0.000 | -2.0 | 0.000 | |||
| merck-ENSMUST00000063029_at | Chrdl1 | 83453 | -1.7 | 0.010 | -1.6 | 0.043 | -1.4 | 0.069 | |||
| merck-NM_172874_at | Podn | 242608 | -1.8 | 0.002 | -1.5 | 0.045 | -1.7 | 0.002 | |||
| merck-AK190654_a_at | C2 | 12263 | -1.8 | 0.005 | -1.5 | 0.036 | -1.6 | 0.010 | |||
| merck-NM_008317_at | Hyal1 | 15586 | -2.3 | 0.000 | -1.6 | 0.001 | -1.7 | 0.000 | -5.2 | -4.7 | -5.8 |
| merck-NM_001039701_a_at | Il1rn | 16181 | -2.3 | 0.069 | -1.7 | 0.080 | -1.2 | 0.528 | |||
| merck-NM_018780_at | Sfrp5 | 54612 | -2.5 | 0.017 | -4.4 | 0.017 | -1.6 | 0.035 | -0.5 | -0.8 | -3.7 |
| merck-NM_011704_at | Vnn1 | 22361 | -2.6 | 0.000 | -1.8 | 0.061 | -1.8 | 0.011 | |||
| merck-NM_009140_at | Cxcl2 | 20310 | -4.7 | 0.003 | -1.6 | 0.044 | -2.0 | 0.042 | |||
Listed are the top 20 potential secreted proteins (in addition to IL1rn), out of 334, that were regulated by a single 2.5 mg/kg dose of PEG30-FGF21 Q108 (1.2 fold and p<0.05) in at least one of the three white adipose tissues (IWAT, EWAT, RPWAT). The 334 probe sets, from which the 20 were derived, are listed in Table S7.