Table 1.
Nominal value for the parameters and MINLP best solution
| Parameter | Nominal value | MINLP solution |
|---|---|---|
|
k2 |
5.18E+07 |
4.74E+07 |
|
k3 |
9.76E+01 |
1.20E+02 |
|
α |
5.79E-02 |
5.23E-02 |
|
ktr |
1.00E+03 |
8.66E+02 |
|
ktl |
4.96E+03 |
4.28E+03 |
|
ktl2 |
1.03E+03 |
1.27E+03 |
|
ktl3 |
2.05E+03 |
1.64E+03 |
|
kz |
4.99E+01 |
6.06E+01 |
|
kd2 |
1.00E+01 |
1.25E+01 |
|
DNA0 |
6.16E-04 |
7.08E-04 |
|
Ka |
1.82E-07 |
2.11E-07 |
|
K |
1.00E+03 |
8.48E+02 |
|
kd |
1.18E+00 |
9.55E-01 |
|
khy |
2.00E+06 |
1.76E+06 |
|
ktransf |
9.74E-01 |
8.07E-01 |
|
kdegf |
1.36E-01 |
1.84E-01 |
|
khy |
- |
- |
|
n1: |
3 |
3 |
|
n2: |
1 |
1 |
|
n3: |
2 |
3 |
|
n4: |
3 |
3 |
|
n5: |
0 |
0 |
|
bin1: |
1 |
1 |
|
bin2: |
1 |
1 |
| bin3: | 0 | 0 |
The bounds for the real parameters were taken at 50% and 200% around the initial values and for the integers they are based on the typical values of Hill coefficients, from 0 to 3. The value of parameter khy is not reported because it is inactive when bin3 = 0.