Table 1. Dysregulated genes in BRIP1-knockdown cells during acinar morphogenesis (ANOVA, P<0.05; fold change ≥5.0).
| Gene symbol | Name | GenBank ID | Fold change* | ||
| 4d | 8d | 12d | |||
| PCSK5 | Proprotein convertase subtilisin/kexin type 5 | NM_006200 | 54.3 | 25.8 | 22.7 |
| RICH2 | Rho-type GTPase-activating protein RICH2 | NM_014859 | 17.2 | 64.5 | 44.3 |
| SATB1 | SATB homeobox 1, transcript variant 1 | NM_002971 | 12.9 | 8.8 | 9.1 |
| LINGO2 | Leucine rich repeat and Ig domain containing 2 | NM_152570 | 7.9 | 7.4 | 7.4 |
| FEZ1 | Fasciculation and elongation protein zeta 1 (zygin I), transcript variant 1 | NM_005103 | 7.4 | 7.6 | 5.3 |
| none | cDNA FLJ61137 complete cds, highly similar to Zinc finger protein 302 | AK297551 | 6.2 | 4.8 | 4.2 |
| C11orf20 | Chromosome 11 open reading frame 20 | NM_001039496 | 6.0 | 2.6 | 1.9 |
| LRG1 | Leucine-rich alpha-2-glycoprotein 1 | NM_052972 | 2.8 | 5.3 | 4.9 |
| CACNA2D3 | Calcium channel alpha2-delta3 subunit | AJ272268 | –2.0 | –5.3 | –4.7 |
| CRLF1 | Cytokine receptor-like factor 1 | NM_004750 | –2.2 | –4.2 | –6.0 |
| CD36 | CD36 molecule (thrombospondin receptor), transcript variant 2 | NM_001001547 | –2.4 | –5.1 | –3.9 |
| MCAM | Melanoma cell adhesion molecule | NM_006500 | –3.0 | –2.2 | –5.0 |
| ADH1C | Alcohol dehydrogenase 1C (class I), gamma polypeptide | NM_000669 | –3.0 | –5.7 | –6.6 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | NM_003881 | –3.2 | –8.1 | –11.5 |
| ISYNA1 | Inositol-3-phosphate synthase 1, transcript variant 1 | NM_016368 | –3.2 | –6.7 | –3.3 |
| ADH1A | Alcohol dehydrogenase 1A (class I), alpha polypeptide | NM_000667 | –3.9 | –10.6 | –5.5 |
| SRGN | Serglycin | NM_002727 | –5.2 | –4.0 | –2.8 |
| COL8A1 | Collagen, type VIII, alpha 1, transcript variant 1 | NM_001850 | –5.8 | –8.6 | –4.1 |
| SNED1 | Sushi, nidogen and EGF-like domains 1 | NM_001080437 | –6.0 | –2.8 | –1.7 |
| COL8A1 | Collagen, type VIII, alpha 1 | AL359062 | –6.4 | –9.7 | –7.7 |
| PTGFR | Prostaglandin F receptor (FP), transcript variant 2 | NM_001039585 | –8.3 | –4.6 | –7.0 |
| CDA | Cytidine deaminase | NM_001785 | –8.8 | –11.0 | –8.1 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | NM_007038 | –9.2 | –10.0 | –6.3 |
| WIPF1 | WAS/WASL interacting protein family, member 1, transcript variant 2 | NM_001077269 | –10.2 | –6.3 | –8.0 |
| HSD11B1 | Hydroxysteroid (11-beta) dehydrogenase 1, transcript variant 2 | NM_181755 | –11.9 | –6.8 | –3.6 |
*
A positive fold change indicates increased expression in the BRIP1-knockdown cells, and a negative fold change indicates decreased expression in the cells compared with control cells.