Table 4. Diagnostic values of QFT-GIT in active pulmonary TB patients stratified by HIV status calculated over the total of patients tested (indeterminate results included as negative results) and only over the interpretable results (indeterminate results excluded).
HIV status | Indeterminate results included as negative results | Indeterminate results excluded | |||||||
Sensitivity | Specificity | LR+ | LR− | Sensitivity | Specificity | LR+ | LR− | ||
Percentage (95% CI) | Percentage (95% CI) | ||||||||
HIV-infected | 68.4 (51.4–82.5) | 64.8 (50.6–77.3) | 1.95 | 2.05 | 89.7 (72.7–97.8) | 60.4 (45.3–74.2) | 2.26 | 5.86 | |
HIV-uninfected | 91.4 (81.0–97.1) | 58.2 (44.1–71.4) | 2.19 | 6.77 | 94.6 (85.1–98.9) | 58.2 (44.1–71.4) | 2.26 | 10.78 | |
Total | 82.3(73.2–89.3) | 61.5 (51.7–70.6) | 2.13 | 3.48 | 92.9 (85.3–97.4) | 59.2 (49.1–68.8) | 2.27 | 8.34 |
Footnotes: QFT-GIT: QuantiFERON® Gold in Tube; HIV: human immunodeficiency virus; TB: tuberculosis; PPV: positive predictive value; NPV: negative predictive value; LR+: positive likelihood ratio; LR.-: negative likelihood ratio.