Table 6. Sensitivity of QFT-GIT calculated over the total of patients tested (indeterminate results included as negative results) and only over the interpretable results (indeterminate results excluded) in PTB patients stratified by HIV status according to smear microscopy status.
Indeterminate results included as negative results | Indeterminate results excluded | |||||
AFB-positive | AFB-negative | P (AFB- negative versus AFB -positive) | AFB-positive | AFB-negative | P (AFB- negative versus AFB -positive) | |
Positive over total % (95% CI) | ||||||
HIV-infected | 12/19 | 14/19 | 12/12 | 14/17 | ||
63.2 (38.4–83.4) | 73.7 (48.8–90.9 | 0.7281 | 100.0 (73.5–100) | 82.4 (56.6–96.2) | 0.2463 | |
HIV-uninfected | 43/46 | 10/12 | 43/44 | 10/12 | ||
93.5 (82.1–98.6) | 83.3 (51.6–97.9) | 0.2735 | 97.7 (88.0–99.9) | 83.3 (51.6–97.9) | 0.1127 | |
Total | 55/65 | 24/31 | 55/56 | 24/29 | ||
84.6 (73.5–92.4) | 77.4 (58.8–90.4) | 0.4031 | 98.2 (90.5–99.9) | 82.8 (64.2–94.2) | 0.0163 |
Footnotes: QFT-GIT: QuantiFERON® Gold in Tube; TB: Tuberculosis; HIV: Human Immunodeficiency Virus, AFB: Acid Fast Bacilli.