Table 3.
Genotype and allele frequencies of rs9770242 by CAD status
| |
N |
rs9770242 |
OR (95% CI) |
P |
|||
|---|---|---|---|---|---|---|---|
| MAF | TT | TG | GG | ||||
| Brazilian cohort |
|
|
|
|
|
|
|
| Without CAD |
188 |
0.245 |
0.582 (n = 109) |
0.351 (n = 66) |
0.067 (n = 13) |
1 |
|
| With CAD |
406 |
0.201 |
0.639 (n = 259) |
0.323 (n = 131) |
0.038 (n = 16) |
1.36 (1.01 – 1.86)a |
0.05 |
| 1.46 (1.06 – 2.01)b |
0.02 |
||||||
| North-American cohort |
|
|
|
|
|
|
|
| Without CAD |
434 |
0.247 |
0.562 (n = 244) |
0.383 (n = 166) |
0.055 (n = 24) |
1 |
|
| With CAD | 424 | 0.245 | 0.543 (n = 230) | 0.424 (n = 180) | 0.033 (n = 14) | 1.02 (0.76 – 1.22)c | 0.73 |
OR (odds ratio) in a codominant model for the T-allele determined in logistic regression analyses.(a)Adjusted for sex, age and glycemic status; (b)adjusted for sex, age, glycemic status, BMI, blood pressure, dyslipidemia and NAMPT levels; (c)adjusted for age and sex. MAF: minor allele frequency. Hardy-Weinberg equilibrium: Brazilian cohort, without CAD (p = 0.49), with CAD (p = 0.91); North-American cohort, without CAD (p = 0.54), with CAD (p = 0.003).