Figure 5. Oro-gastric (og) administration of NGD CRF₁ antagonist, NGD 98-2 or NGD 9002 reduces acute water avoidance stress (WAS)-induced stimulation of colonic propulsive motor function in rats.

Vehicle or NGD 98-2 (A) or NGD 9002 (B) at 3, 10 and 30 mg/kg was administered po and 180 min later (for NGD 98-2 group) or 60 min later (for NGD 9002 group), rats were exposed to WAS for 60 min. FPO was monitored during the 60 min stress session. Each bar represents the mean and SEM of 8 rats/group. *p<0.05 compared with vehicle og+no stress; ^#p<0.05 compared with vehicle og+WAS, ANOVA, Student-Newman-Keuls.