Table 3. Impact of deletion of variable regions of Nhha on the induction of complement-mediated killing by bactericidal antibodies in mice in synergy with anti-TbpA OMVs sera using pooled sera.
| Mix of serab | H44/76 SBAa | CU385 SBAa |
| a-TbpA OMVs+control negative pooled sera | 778 | 532 |
| a-TbpA OMVs+a- NhhAPMC21 OMVs | 2595a | 1438 |
| a-TbpA OMVs+a- NhhABgl OMVs | 4383 | 2891 |
| a-TbpA OMVs+a- NhhASO1 OMVs | 1568 | 742 |
a
SBA = Serum Bactericidal Assay, Geometric mean titers for 50% killing.
b
NhhAPMC21, wild type NhhA; NhhABgl, NhhA without variable regions 1&2; NhhASO1, NhhA without variable regions 1 to 4.