Figure 5.

A RanGTP gradient regulates ciliary and nuclear trafficking. For ciliary trafficking, the ciliary localization sequence of KIF17 interacts with Importin-β2 for trafficking through the ciliary pore complex into the ciliary compartment where the high Ran-GTP concentration (blue shading) dissociates the complex. For nuclear trafficking, the nuclear localization sequence of a nuclear protein interacts with an importin receptor for trafficking across the nuclear pore complex into the nuclear compartment where the high RanGTP concentration (blue shading) dissociates the complex. RanGTP, Ran-guanosine triphosphate.