Figure 5. 53BP1 sensitizes breast cancer to 5-Fu in vivo.
(A) Growth curves of mammary tumors for control and 53BP1 overexpressing MDA-MB-231 cells with 5-Fu or vehicle. (B) Growth curves of tumors for control and 53BP1 knockdown MCF-7 cells with 5-Fu or vehicle. Tumor diameter was measured with calipers and the tumor volume was calculated by the formula: (width)2 × length/2. Each group consisted of seven mice. Error bars represent ± SD. (C) Representative tumors isolated from mice after implantation with control or 53BP1 over expressing MDA-MB-231 cells and treated with 5-Fu or vehicle as described in panel A. (D) Representative tumors isolated from mice after implantation with control or 53BP1 knockdown MCF-7 cells and treated with 5-Fu or vehicle as described in panel B.