Table 4. Type of antioxidant supplement, dose, all-cause mortality, accrued information size (AIS), and diversity-adjusted required information size (DARIS).

Antioxidants	Dose range and divided according to RDA*	Trials N	All-cause mortality (RR, 95% CI)	AIS	DARIS
Beta-carotene singly	25-50 mg	7	1.06 [1.02, 1.10]	43,019	110,505
Beta-carotene singly or combined	1.2-50 mg	26	1.05 [1.01, 1.09]	173,006	261,708
	≤ 9.6 mg*	6	0.90 [0.69, 1.17]	14,285	267,631
	> 9.6 mg*	20	1.06 [1.02, 1.09]	158,721	190,906
Vitamin A singly	667-7500 µg	2	1.18 [0.83, 1.68]	1323	110,505
Vitamin A singly or combined	400-60000 µg	12	1.07 [0.97, 1.18]	41,144	394,010
	≤ 800 µg*	8	1.05 [0.65, 1.69]	1415	456,748
	> 800 µg*	4	1.08 [0.98, 1.19]	38,570	415,996
Vitamin E singly	50-5000 mg	20	1.02 [0.98, 1.05]	58,904	110,505
Vitamin E singly or combined	10-5000 mg	46	1.03 [1.00, 1.05]	70,836	110,505
	≤ 15 mg*	2	1.32 [0.51, 3.46]	563	119,364
	> 15 mg*	44	1.03 [1.00, 1.05]	170,219	110,505

Abbreviations: RDA - recommended dietary allowance; CI – confidence interval; N – number of trials; n – number of participants; AIS – accrued information size; DARIS – diversity-adjusted required information size; n/a – not available

^*calculated based on retinol equivalents