Table 2.
Characteristics and independent risk factors of liver steatosis in Chinese HIV patients with hypertriglyceridemia analyzed with univariate and multivariate regression analysis
| |
|
|
|
Univariate analysis |
Mutivariate analysis |
||
|---|---|---|---|---|---|---|---|
| Charateristics | All patients | Liver steatosis | Non-steatosis | OR | P value | OR | P value |
|
Features |
|
|
|
|
|
|
|
| Age (yr) |
42.9 ± 9.3 |
43.2 ± 9.5 |
42.9 ± 9.2 |
0.99 |
0.79 |
|
|
| Male |
109 (66.9%) |
52 (31.9%) |
57 (35.0%) |
0.47 |
0.02 |
|
|
| Female |
54 (33.1%) |
36 (22.1%) |
18 (11.0%) |
||||
| Smoking histroy |
52 (31.9%) |
27 (30.7%) |
25 (33.3%) |
1.13 |
0.72 |
|
|
| Drinking |
17 (10.4%) |
12 (13.6%) |
5 (6.7%) |
4.615 |
0.03 |
|
|
|
BMI (Kg/m2) |
|
|
|
|
|
|
|
| Male patients |
|
|
|
|
|
|
|
| 25-29.9 |
76 (69.7%) |
41 (37.6%) |
35 (32.1%) |
0.68 |
0.71 |
|
|
| ≥30 |
13 (11.9%) |
6 (5.5%) |
7 (6.4%) |
|
|
|
|
| 18.6-24.9 |
20 (18.4) |
11 (10.1%) |
9 (8.3%) |
|
|
|
|
| Female patients |
|
|
|||||
| 25-29.9 |
36 (66.7%) |
12 (22.2%) |
24 (44.5%) |
<0.001 |
1.00 |
|
|
| ≥30 |
6 (11.1%) |
2 (3.7%) |
4 (7.4%) |
||||
| 18.6-24.9 |
12 (22.2%) |
4 (7.4%) |
8 (14.8%) |
||||
|
Biochemistry tests |
|
|
|||||
| ALT (U/L) |
32.5 ± 29.3 |
28.8 ± 25.7 |
36.7 ± 32.7 |
1.01 |
0.11 |
|
|
| AST (U/L) |
31.7 ± 30.9 |
37.7 ± 32.1 |
31.3 ± 21.5 |
0.99 |
0.78 |
|
|
| CK |
115 ± 112 |
131 ± 186 |
109 ± 62 |
0.99 |
0.44 |
|
|
| BUN (mmol/L) |
4.9 ± 1.4 |
4.8 ± 1.0 |
4.9 ± 1.8 |
1.04 |
0.55 |
|
|
| Cr (umol/L) |
77.0 ± 28.5 |
82.3 ± 18.7 |
70.9 ± 35.9 |
0.97 |
0.01 |
|
|
|
Blood lipid levels |
|
|
|||||
| TG (mmol/L) |
5.7 ± 5.2 |
4.7 ± 3.8 |
6.9 ± 6.3 |
1.10 |
0.012 |
1.086 |
0.026 |
| TC (mmol/L) |
5.5 ± 1.7 |
5.3 ± 1.7 |
5.8 ± 1.7 |
1.19 |
0.07 |
|
|
| LDL (mmol/L) |
2.8 ± 1.0 |
2.9 ± 0.9 |
2.7 ± 1.1 |
0.83 |
0.31 |
|
|
| HDL (mmol/L) |
1.3 ± 0.3 |
1.3 ± 0.3 |
1.2 ± 0.4 |
0.37 |
0.08 |
|
|
| FPG (mmol/L) |
5.7 ± 1.8 |
5.1 ± 1.2 |
6.5 ± 2.1 |
1.90 |
<0.001 |
|
|
|
Metabolic sydrome |
78 (47.9%) |
34 (38.6%) |
44 (58.7%) |
2.25 |
0.01 |
2.092 |
0.024 |
|
HIV infection |
|
|
|
|
|
|
|
| Time since HIV |
132 ± 73 |
141 ± 74 |
117 ± 69.5 |
0.99 |
0.07 |
|
|
| diagnosis (M) |
|
|
|
|
|
|
|
| Mos. on ART (M) |
38.7 ± 25.3 |
37.5 ± 25.3 |
40.1 ± 25.5 |
1.00 |
0.39 |
|
|
| Current CD4 | 316 ± 191 | 240 ± 141 | 401 ± 204 | 1.01 | <0.001 | ||
Notes:BMI body metabolic index, ALT Alanine aminotransferase, AST Aspartate aminotransferase, CK Creatine kinase, BUN Blood urea nitrogen, Cr Serum creatinine, TG triglyceride, TC Total cholesterol, LDL Low-density lipoprotein, HDL high-density lipoprotein, FPG Fasting plasma glucose.