Table 3.
Comparison of key parameters in Chinese RM and Indian RM following SIV infection
| Innoculation route | SIV strains (Titer) | Rhesus macaque | Peak viral load (lg10) | Set point viral load (lg10)* | CD4 + T cells (%) | Antibody titer** | Survival time*** | Ref |
|---|---|---|---|---|---|---|---|---|
| I.V. |
mac239 |
Chinese RM (n = 10) |
6.5–7.8 |
~2.8–6.7 |
>50% (7 out of 10) |
10 out of 10 positive |
NP |
[20] |
| (102 TCID50) |
Indian RM (n = 4) |
7–8 |
~6–7 |
<50% (2 out of 4) |
1 out of 4 |
>17W (2/4) |
||
| mac251 |
Chinese RM (n = 8) |
5.8–7.5 |
2.5–5.8 |
NP |
NP |
>154W (4/8) |
[40] |
|
| (10 TCID50) |
Indian RM (n = 6) |
6.9–7.8 |
4.5–7.3 |
NP |
NP |
<52W |
||
| mac251 |
Chinese RM (n = 8) |
6.47–7.88 |
3.62–5.70 |
51% |
~103 |
>43W (8/8) |
[8] |
|
| (102 TCID50) |
Indian RM (n = 15) |
6.64–8.30 |
4.37–7.30 |
49% |
~103 |
>43W(10/15) |
||
| IVAG | mac251 |
Chinese RM (n = 10) |
7.2 |
5.0 |
NP |
1.6 × 104–8 × 105 |
NP |
[22] |
| (105 TCID50) | Indian RM (n = 16) | 7.7 | 6.3 | NP | 2 × 102–8 × 105 | NP |
*: Measured at day 35–77;
**: Measured at wk15-16;
****W: Weeks.