Table 1.

SHAPE-2 study inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Female	Presently using sex hormones
50-69 years of age	Use of beta-blockers or oral corticosteroids
Postmenopausal (last menses >12 months)	Smoking
Body mass index (BMI) 25–35 m/kg2	Alcohol or drug abuse
Sedentary lifestyle (<2 hours/week of at least moderately intensive activities (≥4 MET))	Diagnosed with breast cancer (present or history)
Willing to be randomly assigned to one of the three study arms	Diagnosed with other cancer (present or <5 years of history), except fornon-melanoma skin cancer
Informed consent for all screening and study activities	Diabetes mellitus or other (unstable) endocrine related diseases
	Any disorder that might impede participation in the exercise programme
	Following, or intention to follow, a structured weight loss programme elsewhere
	Investigators opinion (successful fulfilling of the programme is highly unlikely)