Figure 4.

Sections of soleus muscle specimens from the 6-week group, nonexercised side (a, b) and the 1-week group, exercised side (c), and of gastrocnemius muscle specimen from the 1 week group, exercised side (d, e). Abnormal muscle fibers, that is, muscle fibers being completely infiltrated by white blood cells, are shown. Such a fiber is seen in the middle in (a) (H&E staining). There are cellular NK-1R immunoreactions in this fiber (b) (arrows). There are also cellular NK-1R immunoreactions in (c) and (d) (arrows indicate immunoreactive cells). (d) and (e) represent double staining for NK-1R (d) and SP (e). There is colocalization (arrows). M = ordinary muscle fibers. Bars = 25 μm.