Table 2.
Number (N) and prevalence (%) of pure/mixed pfcrt, pfmdr1, pfdhfr and pfdhps mutant alleles conferring resistance to chloroquine and sulphadoxine-pyrimethamine in Plasmodium falciparum isolates from Pakistan
| |
|
Pure |
Mixed |
|---|---|---|---|
| Gene | Allele or haplotype | N (%) | N (%) |
|
pfcrt |
SVMNT/ K76T |
171 (100) |
0 (0) |
|
pfmdr1 |
N86Y |
6 (4) |
28 (16) |
| |
Y184F |
0 (0) |
43 (25) |
| |
S1034C |
0 (0) |
0 (0) |
| |
N1042D |
0 (0) |
165 (96) |
| |
D1246Y |
0 (0) |
0 (0) |
|
pfdhfr |
pfdhfr triple (N51I + C59R + S108N) |
0 (0) |
7 (4) |
| |
pfdhfr double (N51I + S108N) |
11 (6) |
3 (2) |
| |
pfdhfr double (C59R + S108N) |
148 (87) |
9 (5) |
|
pfdhps |
pfdhps double (A437G + K540E) |
4 (2) |
77 (45) |
| |
pfdhps A437G |
103 (60) |
3 (2) |
| |
pfdhps K540E |
6 (4) |
131 (77) |
| |
pfdhps A581G |
5 (3) |
66 (39) |
| pfdhfr + pfdhps | pfdhfr + pfdhps (C59R + S108N + A437G) | 88 (51) | 6 (4) |