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Clinically important change in MacNew Global score (≥0.5) between baseline and follow-up. Percentages of patients improving, deteriorating or staying stable (A) and percentages of patients improving or deteriorating for the first time relative to the baseline score at the respective point of time (B). (t0: baseline; t1: 1 month; t2: 6 months; t3: 12 months, t4: 24 months).
