Skip to main content
. 2013 Aug 20;10:102. doi: 10.1186/1742-2094-10-102

Figure 6.

Figure 6

ApoE3-TR mice have increased ability to upregulate neurogenesis upon ischemic injury. Newly born neurons were visualized by doublecortin (DCX) staining at 10 days post ischemia. (A) DCX-positive cells were quantified from the subventricular zone of both hemispheres and the values are presented as a ratio between ipsilateral and contralateral hemispheres. * p < 0.05 and ** p < 0.01. Typical example images of DCX immunoreactivity in the subventricular zone in the ipsilateral hemisphere of: (B) sham-operated wild-type (WT) mice on a normal diet (ND, n = 7), (C) ischemic WT mice on a ND (n = 6) and (D) on a high-fat (HF) diet (n = 5), (E) sham-operated ApoE3-TR mice on normal diet (n = 5), (F) ischemic ApoE3-TR mice on normal diet (n = 6) and (G) on a HF diet (n = 6), (H) sham-operated ApoE4-TR mice on normal diet (n = 9), and (I) ischemic ApoE4-TR mice on normal diet (n = 6) and (J) on a HF diet (n = 5). Dashed line, lining of the ventricular wall; asterisks, lateral ventricle on the ipsilateral hemisphere. ApoE, apolipoprotein E; E3, E4 and WT, ApoE3-TR, ApoE4-TR and control mice; Sham and Isch, sham-operated and ischemic mice; TR, targeted replacement. Data expressed as mean ± standard error of the mean. Scale bar = 100 μm.