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. 2013 Aug 28;8:29. doi: 10.1186/1750-1326-8-29

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Copyright © 2013 Sunico et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increased S-nitrosylation of parkin and p53 levels in a mouse model of PD. Levels of S-nitrosylated parkin (SNO-parkin), total parkin, p53, and actin were examined by biotin-switch and western blot in mice treated with the nNOS inhibitor 3-Br-7-NI, PQ/MB, or PQ/MB with 3-Br-7-NI (left panel). Ratios of SNO-parkin and total parkin were quantified to indicate the extent of parkin S-nitrosylation under the indicated conditions (center panel). Quantifications of p53 signal were normalized to actin (right panel). Values are mean + SEM, n = 3 mice per condition; * p < 0.05.