Table 3.
Molecular fingerprint of LGGs composed by the selected 15 genes
| Gene/Locus | Description | Biological Process |
|---|---|---|
| FOXG1 / 14q13 |
forkhead box G1 |
GO:0007417 CNS development GO:0022008 neurogenesis |
| |
|
GO:0030900 forebrain development GO:0048699 generation of neurons |
| |
|
GO:0021954 CNS neuron development GO:0021953 CNS neuron differentiation |
| |
|
GO:0048666 neuron development GO:0007423 sensory organ development |
| |
|
GO:0043583 ear development GO:0009953 dorsal/ventral pattern formation |
| |
|
GO:0006355 regulation of transcription, DNA-dependent |
| |
|
GO:0051252 regulation of RNA metabolic process |
| |
|
GO:0045449 regulation of transcription |
| |
|
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid |
| |
|
GO:0048667 cell morphogenesis involved in neuron differentiation |
| |
|
GO:0048812 neuron projection morphogenesis |
| |
|
GO:0048858 cell projection morphogenesis GO:0032990 cell part morphogenesis |
| |
|
GO:0031175 neuron projection development |
| GPR17 / 2q21 |
G protein-coupled receptor 17 |
GO:0007165 signal trasduction |
| |
|
GO:0007186 G-protein coupled receptor protein signaling pathway |
| CXCL14 / 5q31 |
chemokine (C-X-C motif) |
GO:0006995 immune response GO: 0006935 chemotaxis |
| |
ligand 14 |
GO:0007267 cell-cell signaling GO:0007165 signal trasduction |
| ARX / Xp21 |
aristaless related homeobox |
GO:0007417 CNS development, GO:0022008 neurogenesis |
| |
|
GO:0030900 forebrain development, GO:0048699 generation of neurons |
| |
|
GO:0021954 CNS neuron development, GO:0021987 cerebral cortex development |
| |
|
GO:0021543 pallium development |
| |
|
GO:0006355 regulation of transcription, DNA-dependent |
| |
|
GO:0051252 regulation of RNA metabolic process |
| |
|
GO:0045449 regulation of transcription |
| |
|
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid |
| |
|
GO:0048667 cell morphogenesis involved in neuron differentiation |
| |
|
GO:0048812 neuron projection morphogenesis |
| |
|
GO:0048858 cell projection morphogenesis |
| |
|
GO:0032990 cell part morphogenesis |
| |
|
GO:0031175 neuron projection development |
| LHX2 / 9q33q34.1 |
LIM homeobox 2 |
GO:0007417 CNS development GO:0022008 neurogenesis |
| |
|
GO:0030900 forebrain development GO:0048699 generation of neurons |
| |
|
GO:0048666 neuron development GO:0009953 dorsal/ventral pattern formation |
| |
|
GO:0006355 regulation of transcription, DNA-dependent |
| |
|
GO:0051252 regulation of RNA metabolic process |
| |
|
GO:0045449 regulation of transcription |
| |
|
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid |
| |
|
GO:0048667 cell morphogenesis involved in neuron differentiation |
| |
|
GO:0048812 neuron projection morphogenesis |
| |
|
GO:0048858 cell projection morphogenesis |
| |
|
GO:0032990 cell part morphogenesis, GO:0031175 neuron projection development |
| TIMP4 / 3p25 |
TIMP metallopeptidase |
GO:0007417 CNS development GO:0009725 response to hormone stimulus |
| |
inhibitor 4 |
GO:0032496 response to lipopolysaccharide |
| |
|
GO:0034097 response to cytokine stimulus |
| APOD / 3q26.2qter |
apolipoprotein D |
GO.0006629 lipid metabolic process |
| PTGD2S / 9q34.2-34.3 |
prostaglandin D2 synthase |
GO:0006633 fatty acid biosynthetic process |
| |
21 kDa (brain) |
GO:0006810 transport |
| SDC3 / 1pter-p22.3 |
syndecan 3 |
GO:0007155 cell adhesion |
| NRXN2 / 11q13 |
neurexin 2 |
GO:0007268 synaptic trasmission GO:0007269 neurotransmitter secretion |
| |
|
GO:0007416 synapse assembly GO:0007155 cell adhesion |
| SNX22 / 15q22.31 |
sorting nexin 22 |
GO:0007165 signal trasduction GO:0007154 cell comunication |
| ZFHX4 / 8q21.11 |
zinc finger homeobox 4 |
GO:0006355 regulation of transcription, DNA-dependent |
| |
|
GO:0051252 regulation of RNA metabolic process |
| |
|
GO:0045449 regulation of transcription |
| |
|
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid |
| |
|
GO:0015031 protein transport |
| SPOCK1 / 5q31 |
testican 1 |
GO:0007417 CNS development GO:0007165 signal trasduction |
| |
|
GO:0007155 cell adhesion |
| ABBA1 / 16q22.1 |
metastasis suppressor 1 like |
GO:0007165 signal trasduction |
| FOSB / 19q13.32 |
FBJ murine osteosarcoma |
GO:0006355 regulation of transcription, DNA-dependent |
| |
viral oncogene homolog B |
GO:0051252 regulation of RNA metabolic process |
| |
|
GO:0045449 regulation of transcription |
| GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid |
Gene annotations and GO Biological Process terms for the minimal list of 15 genes, selected for the biologically validated molecular fingerprint of LGGs related to site of lesion (infratentorial vs supratentorial).