Table 1.
Characteristics of GWAS subjects
| |
CAMP |
CARE§ |
ACRN¶ |
LHS |
DAG| |
|---|---|---|---|---|---|
| (n = 525) | (n = 195) | (n = 274) | (n = 3,354) | (n = 650) | |
| Age - Mean (SD) |
8.8 (2.1) |
10.6 (2.9) |
31.5 (10.3) |
48.8 (6.7) |
36.0 (13.8) |
| Gender – N (%) Male |
322 (61) |
123 (63) |
118 (43) |
1949 (58.1) |
291 (45) |
| Wash-out Prior to Methacholine Test* - Weeks |
4 |
0-4 |
1-6 |
- |
- |
| LnPC20 |
0.096 (1.21) |
−0.25 (1.35) |
0.80 (0.68) |
1.58 (0.93) |
0.71 (1.63) |
| Current smokers |
0 (0) |
0 (0) |
0 (0) |
3,354 (100) |
106 (16) |
| Baseline FEV1 |
1.7 (0.5) |
2.2 (0.8) |
3.2 (0.8) |
2.7 (0.6) |
2.8 (0.9) |
| Baseline FEV1 % Predicted |
94.4 (14.1) |
98.8 (13.0) |
86.8 (13.5) |
78.2 (10.0) |
82.3 (20.5) |
| Height [cm] |
132.8 (13.6) |
143.4 (16.8) |
170.3 (10.0) |
171.3 (8.9) |
172.1 (11.5) |
| Weight [kg] |
32.4 (10.9) |
42.9 (18.1) |
75.6 (18.2) |
75.1 (14.8) |
74.7 (17.6) |
| BMI [kg/cm^2] | 17.9 (3.1) | 20.1 (4.9) | 25.9 (5.3) | 25.5 (3.9) | 25.0 (4.8) |
*Subjects were allowed to use rescue medication during wash-out period.
§CARE trials included: CLIC, PACT, MARS.
¶ACRN trials included: BAGS, DICE, IMPACT, PRICE.
|The LnPC20 of the DAG cohort was calculated for 600 of the 650 asthmatics in the analysis.
Mean (Standard deviation) reported unless otherwise noted. CAMP, CARE, ACRN, and DAG are composed of subjects with asthma and not COPD, while LHS is composed of subjects with COPD who did not have asthma at the time of enrollment but may have had a past history of asthma.