Table 3.
Genotypic distribution of 3DS1/3DL1 and the ligand among individuals in different groups
|
Allele genotype, ligand |
1Low CD4 |
2High CD4 |
P |
3High VL |
4Low VL |
P |
5TP |
6LTNP |
P |
|---|---|---|---|---|---|---|---|---|---|
|
(Total 83) |
(Total 49) |
(Total 84) |
(Total 48) |
(Total 83) |
(Total 40) |
||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
| 3DS1/3DL1 |
20 (24.1) |
19 (38.8) |
0.057 |
23 (27.4) |
16 (33.3) |
0.299 |
20 (24.1) |
15 (37.5) |
0.093 |
| 3DS1/3DS1 |
2 (2.4) |
3 (6.1) |
0.266 |
2 (2.4) |
3 (6.3) |
0.253 |
2 (2.4) |
3 (7.5) |
0.194 |
| 3DL1/3DL1 |
61 (73.5) |
27 (55.1) |
0.025 |
59 (70.2) |
29 (60.4) |
0.169 |
61 (73.5) |
22 (55.0) |
0.033 |
| 3DS1/?, with 80I |
2 (2.4) |
9 (18.4) |
0.002 |
7 (8.3) |
4 (8.3) |
0.636 |
2 (2.4) |
9 (22.5) |
0.001 |
| 3DL1/?, with 80I |
11 (13.3) |
15 (30.6) |
0.015 |
13 (15.5) |
13 (27.1) |
0.084 |
11 (13.3) |
14 (35.0) |
0.006 |
| 3DS1/3DS1, with 80I |
0 (0.0) |
0 (0.0) |
|
0 (0.0) |
0 (0.0) |
|
0 (0.0) |
0 (0.0) |
|
| 3DL1/3DL1, with 80I |
9 (10.8) |
6 (12.2) |
0.508 |
6 (7.1) |
9 (18.8) |
0.043 |
9 (10.8) |
5 (12.5) |
0.501 |
| 3DS1/3DL1, with 80I |
2 (2.4) |
9 (18.4) |
0.002 |
7 (8.3) |
4 (8.3) |
0.636 |
2 (2.4) |
9 (22.5) |
0.001 |
| 3DS1/?, no 80I |
20 (24.1) |
13 (26.5) |
0.455 |
18 (21.4) |
15 (31.2) |
0.148 |
20 (24.1) |
9 (22.5) |
0.518 |
| 3DL1/?, no 80I |
70 (84.3) |
31 (63.3) |
0.006 |
69 (82.1) |
32 (66.7) |
0.037 |
70 (84.3) |
23 (57.5) |
0.002 |
| 3DS1/3DS1, no 80I |
2 (2.4) |
3 (6.1) |
0.266 |
2 (2.4) |
3 (6.3) |
0.253 |
2 (2.4) |
3 (7.5) |
0.194 |
| 3DL1/3DL1, no 80I |
52 (62.7) |
21 (42.9) |
0.021 |
53 (63.1) |
20 (41.7) |
0.014 |
52 (62.7) |
17 (42.5) |
0.028 |
| 3DS1/3DL1, no 80I |
18 (21.7) |
10 (20.4) |
0.523 |
16 (19.1) |
12 (25.0) |
0.277 |
18 (21.7) |
6 (15.0) |
0.267 |
| 3DS1/?, with 80 T |
1 (1.2) |
0 (0.0) |
0.629 |
1 (1.2) |
0 (0.0) |
0.636 |
1 (1.2) |
0 (0.0) |
0.675 |
| 3DL1/?, with 80 T |
7 (8.4) |
1 (2.0) |
0.132 |
5 (6.0) |
3 (6.3) |
0.609 |
7 (8.4) |
1 (2.5) |
0.2 |
| 3DL1/3DL1, with 80 T |
6 (7.2) |
1 (2.0) |
0.192 |
4 (4.8) |
3 (6.3) |
0.501 |
6 (7.2) |
1 (2.5) |
0.271 |
| 3DS1/3DL1, with 80 T |
1 (1.2) |
0 (0.0) |
0.629 |
1 (1.2) |
0 (0.0) |
0.636 |
1 (1.2) |
0 (0.0) |
0.675 |
| 3DS1/3DS1, with 80 T |
0 (0.0) |
0 (0.0) |
|
0 (0.0) |
0 (0.0) |
|
0 (0.0) |
0 (0.0) |
|
| 3DS1/?, no 80 T |
21 (25.3) |
22 (44.9) |
0.017 |
24 (28.6) |
19 (39.6) |
0.135 |
21 (25.3) |
18 (45.0) |
0.024 |
| 3DL1/?, no 80 T |
74 (89.2) |
45 (91.8) |
0.431 |
77 (91.7) |
42 (87.5) |
0.314 |
74 (89.2) |
36 (90.0) |
0.579 |
| 3DL1/3DL1, no 80 T |
55 (66.3) |
26 (53.1) |
0.094 |
55 (65.5) |
26 (54.2) |
0.136 |
55 (66.3) |
21 (52.5) |
0.102 |
| 3DS1/3DL1, no 80 T |
19 (22.9) |
19 (53.1) |
0.041 |
22 (26.2) |
16 (33.3) |
0.25 |
19 (22.9) |
15 (37.5) |
0.071 |
| 3DS1/3DS1, no 80 T | 2 (2.4) | 3 (6.1) | 0.266 | 2 (2.4) | 3 (6.3) | 0.253 | 2 (2.4) | 3 (7.5) | 0.194 |
1Low CD4, “low CD4+ T cell count” group (CD4+ T cell counts<500 cells/μl); 2High CD4, “High CD4+ T cell count” group (CD4+ T cell counts ≥ 500 cells/μl); 3High VL, “high viral load” group (HIV viral load ≥ 104 copies/ml); 4Low VL, “low viral load” group (HIV viral load<104 copies/ml); 5TP, HIV typical progressors; 6LTNP, HIV long-term nonprogressors (9 individuals were excluded for the analysis based on LTNPs or TPs, because of not meeting the criterions of LTNPs or TPs).
3DS1/L1, KIR3DS1/L1 heterozygotes; 3DS1/S1, 3DS1 homozygotes; 3DL1/L1, KIR3DL1 homozygotes.
3DS1/?, individuals with at least one copy of KIR3DS1 gene; 3DL1/?, individuals with at least one copy of KIR3DL1 gene.
80I, HLA-Bw4-80I; 80 T, HLA-Bw4-80 T.
n, the number of individuals with each genotype in each group; %, the percentage of individuals with each genotype in each group
Data was calculated by from Yates’s correction or Fisher’s exact test.
Bold numbers indicate P value<0.05.