Table 1.
Genotype and allele frequency distribution of LPA SNPs in CAD patients
|
Subjects |
All patients |
Patients without MACE, n = 415 |
Patients with MACE, n = 102 |
P |
|
|---|---|---|---|---|---|
|
N = 517 | |||||
| SNP ID | n (%) | n (%) | n (%) | ||
| rs6415084 |
Genotype |
|
|
|
|
| |
CC |
406 (78.5) |
367 (78.6) |
39 (78.0) |
0.250 |
| |
CT |
105 (20.3) |
94 (20.1) |
11 (22.0) |
|
| |
TT |
6 (1.2) |
25 (1.3) |
0 (0.0) |
|
| |
Allele |
|
|
|
|
| |
C |
917 (88.7) |
828 (85.2) |
89 (89.0) |
0.302 |
| |
T |
117 (11.3) |
144 (14.8) |
11 (11.0) |
|
| rs3798220 |
Genotype |
|
|
|
|
| |
CC |
433 (83.8) |
393 (84.2) |
40 (68.1) |
0.449 |
| |
CG |
84 (16.2) |
74 (15.8) |
10 (21.3) |
|
| |
Allele |
|
|
|
|
| |
C |
950 (91.9) |
860 (91.1) |
74 (84.1) |
0.870 |
| |
G |
84 (8.1) |
74(8.9) |
14 (15.9) |
|
| rs10455872 |
Genotype |
|
|
|
|
| |
AA |
515 (99.6) |
465 (99.6) |
50 (100.0) |
1.000 |
| |
AG |
2 (0.4) |
2 (0.4) |
0 (0.0) |
|
| |
Allele |
|
|
|
|
| |
A |
1032 (99.8) |
932 (99.8) |
100 (100.0) |
1.000 |
| G | 2 (0.2) | 2 (0.2) | 0 (0.0) |
Abbreviations: CAD coronary artery disease, LPA Lp(a) gene, MACE major adverse cardiovascular event, SNP single nucleotide polymorphism.