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. 2013 Aug 28;11:199. doi: 10.1186/1479-5876-11-199

Figure 2.

Figure 2

Marker expression in HRPCa-2 by immunohistochemistry. In the area where tissue cores were taken to derive TSGs, we observed: (A-B) strong cytoplasmic K18 staining; (C-D) nuclear staining of AR; (E-F) cytoplasmic staining of PSA; (G-H) negative staining for the normal basal cell marker p63; positive staining for cytoplasmic AMACR (G-H) and negative ERG (I-J). In areas away from where tissue cores were taken in the same specimen, we observed nuclear ERG expression in low-grade cancer cells (arrows in K) and staining for nuclear p63 in normal basal epithelial cells (arrows in L). (B), (D), (F), (H), and (J) are higher magnification (40X) of boxed areas in (A), (C), (E), (G), and (I) (10X), respectively. The ERG-positive cells in (J) are endothelial cells, not cancer cells.