Table 2.
Histone H4 mutants exhibiting altered rapamycin sensitivity
| Histone H4 residue | Rapamycin phenotype | Nucleosome location | Source |
|---|---|---|---|
| L10A |
−1 |
Tail |
This study |
| G14A |
−1 |
Tail |
This study |
| K20A |
−1 |
Disk |
This study |
| K20R |
0 |
Disk |
This study |
| K20Q |
−1 |
Disk |
This study |
| L22A |
−1 |
Disk |
This study |
| G28A |
−1 |
Disk |
This study |
| I29A |
−1 |
Buried |
This study |
| S47A |
−1 |
Lateral |
This study |
| S47D |
+1 |
Lateral |
This study |
| S64A |
−1 |
Disk |
This study |
| S64D |
−1 |
Disk |
This study |
| I66A |
−1 |
Buried |
This study |
| V81A |
+1 |
Buried |
This study |
| Y88A |
−1 |
Disk |
This study |
| Y88E |
0 |
Disk |
This study |
| Y88F |
0 |
Disk |
This study |
| G94A |
−1 |
Disk |
This study |
| Y98A |
−1 |
Buried |
This study |
| Y98E |
−1 |
Buried |
This study |
| Y98F |
0 |
Buried |
This study |
|
Total number of H4 mutants screened |
94 |
||
|
Number of H4 mutants with phenotype |
13 |
||
|
Percentage of total H4 mutants with phenotype |
13.8% |
||
|
Percentage of H4 mutants with resistant phenotypes |
7.7% |
||
| Percentage of H4 mutants with sensitive phenotypes | 92.3% | ||