Table 1.
The incidence of virally induced cholestasis and biliary atresia depends on three variable parameters, mouse strain, time (hours post partum) and dosage of Rhesus rotavirus application
| Variable parameter | Cholestasis | Biliary atresia |
|---|---|---|
|
Mouse strain | ||
| Balb/c 55, 71 |
67%-85% |
67%-91% |
| CD 59 |
33% |
46% |
| NMRI 59 |
19% |
50% |
| C57Bl6 67 |
13% |
100% |
| Balb/c-IFN-γ–/–65 |
90%-100% |
20% |
| Balb/c-TNF-α–/–68 |
No data |
86% |
| Balb/c-Mx + −A2G 71 |
65% |
65% |
| WT 129 70 |
30% |
50% |
| A 129 IFN-α/β receptor–/–70 |
79% |
96% |
| G 129 IFN-γ receptor–/–70 |
39% |
86% |
| AG 129 IFN-α/β/ γ receptor–/–70 |
70% |
96% |
|
Age at infection | ||
| 12-24 hours 65, 83 |
80%-86% |
90%-100% |
| 24-48 hours 55 |
61%-85% |
69%-91% |
| 48-72 hours 52, 53 |
13%-42% |
0-17% |
|
Infective dose | ||
| 107* pfu 62 |
100% |
100% |
| 106 pfu 62 |
86% |
100% |
| 105 pfu 62 |
38% |
100% |
| 104 pfu 62 | 0 | 0 |
pfu–plaque forming unit.
* >106 pfu is not recommended, because the early lethality is inacceptably high.