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. 2013 May 27;22(19):3858–3868. doi: 10.1093/hmg/ddt241

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© The Author 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Overexpression of Bbs4-HA and Bbs6-cmyc constructs Phalloidin-rhodamine staining (yellow) and overexpression of Bbs4-HA and Bbs6-myc tagged (white) (A) Overexpression of Bbs4-HA or Bbs6-myc resulted in deficient polymerization of cytoplasmatic F-actin (white arrohead), inhibiting polymerization of actin filaments, compared with neighbouring untransfected cells (white arrows). Those mIMCD3 untransfected confluent cells (white arrows) show a normal pattern of stress fibres. (B) Transfection with empty HA or c-myc control plasmids does not disrupt polymerization, and actin filaments are polymerized correctly. Scale bar 20 μm.