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. 2013 Jun 4;22(19):3894–3905. doi: 10.1093/hmg/ddt244

Figure 3.

Figure 3.

Prolonged GC1 expression and localization and sustained photoreceptor survival in AAV8(Y733F)-hGRK1-mRd3 treated mice. (A) Retinal sections of treated and untreated 4Bnr rd3 mice injected at P14 were labeled for GC1 at P70 and P200. Normal localization of GC1 in the OS layer of treated mice was observed with a substantial ONL indicative of photoreceptor survival. No GC1 expression and significant loss (P70) or absence (P200) of the ONL layer was observed in the untreated retina. (B) Loss in the number of rows of photoreceptor nuclei in the ONL as a function of postnatal age for treated and untreated mice. Data are the mean ± SD for n ≥ 3. (C) OCT image of WT, treated and untreated B4nr rd3 mice injected at P14 and analyzed at P105. White vertical brackets designate the ONL observed in the retinas from WT and treated mice. No ONL was observed in the untreated mice. Representative micrographs are shown from analysis of four mice.