Figure 2.

Scanning electron micrographs of corrosion casts of coronary vasculature. Eight week old mice were induced to express the stable transgene for one or seven days, or left uninduced. A. and C. One day after doxycycline removal (One day off dox), B. Tet-regulated HIF-1α-PPN-HA mice maintained on doxycycline (On Dox), and D. seven days off doxycycline (Seven days off dox). The coronary vessels exhibit rapid neoangiogensis with functional capillary beds by day seven of stable transgene induction. All SEM images focus on coronary vessels.