Table 1.

Schedule of events for study procedures

Week of treatment	Baseline	1	2	4	6	8	10	12	14	16
Physical exam, EKG, demographic information and forms	X
Childhood Experience of Care and Abuse Questionnaire (CECA.Q), and Ways of Coping Checklist (WCC)	X
Drug Use Information	X	X	X	X	X	X	X	X	X	X
Tobacco Craving Questionnaire, smoking questionnaire, Nicotine Dependency Form and CO (smokers only, 30 minutes post cig)	X					X				X
Fertility and Sexual Behavior Questionnaire , menstrual attitude scale	X									X
Urine pregnancy test	X	X	X	X	X	X	X	X	X	X
Vital signs, blood pressure, weight, waist circumference	X	X	X	X	X	X	X	X	X	X
Prolactin	X	X	X	X	X	X	X	X	X	X
Estradiol, progesterone*	X	X	X	X	X	X	X	X	X	X
Salivary cortisol	X					X				X
Risperidone and 9-OHrisperidone plasma levels, thyroid panel including TRH	X					X				X
CBC, Chemistry and full lipid panel (Total cholesterol, triyglycerides, HDL, LDL, VLDL), FBG, HbA1C	X					X				X
Highly sensitivity C- reactive protein (CRP)	X					X				X
Osteocalcin, bone specific alkaline phosphatase, urinary NTx and serum CTx	X			X		X				X
Cytokines	X					X				X
Parathyroid hormone, homocysteine, and 25-hydroxyvitamin D levels	X					X				X
Medication accountability and pill count		X	X	X	X	X	X	X	X	X
BPRS, SANS, CDS. CGI	X	X	X	X	X	X	X	X	X	X
RBANS	X									X
SAS, BAS, SEC	X	X	X	X	X	X	X	X	X	X
AIMS	X									X
SF-36, DAI, FSFI, FSDS-R, ASEX, PGWB	X			X		X		X		X
Menstrual diary** (kept daily) checked	X	X	X	X	X	X	X	X	X	X
Breast examination***	X		X	X	X	X	X	X	X	X
Exit Interview, Perceived Study Benefits										X

*Subjects will be given a salivary test at each visit and will be asked to perform one for the next week, refrigerate and return.

**Phone calls will be made twice weekly to remind the subjects to keep their menstrual diary daily.

***Done by female research staff or nurse (will only be repeated if galactorrhea is noted during baseline).