Table 3.
Effect of APG on the frequency of MN%, NDI and percent inhibition in human lymphocytes treated with MMC in vitro
| Donor | control MN% | NDI | APG MN% | NDI | MMC MN% | NDI | APG + MMC MN% | NDI | (b + c) – a = x | X – y = z | z/y | % inhibition |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| a | b | c | y (observed) | x (expected) | z | z/x% | ||||||
| 1 | 1.00 | 1.70 | 0.80 | 1.70 | 8.00 | 1.60 | 2.20* | 1.71 | 7.80* | 5.60 | 0.717 949 | 71.794 9 |
| 2 | 1.80 | 1.48 | 1.40 | 1.46 | 5.80 | 1.44 | 3.75* | 1.59 | 5.40* | 1.65 | 0.305 556 | 30.555 6 |
| 3 | 1.50 | 1.71 | 1.70 | 1.78 | 4.60 | 1.69 | 2.20* | 1.77 | 4.80* | 2.60 | 0.541 667 | 54.166 7 |
| 4 | 2.60 | 1.69 | 3.40 | 1.45 | 7.40 | 1.49 | 5.80* | 1.45 | 8.20* | 2.40 | 0.292 683 | 29.268 3 |
| 5 | 1.00 | 1.70 | 1.00 | 1.25 | 2.60 | 1.53 | 5.20* | 1.42 | 6.80* | 4.60 | 0.676 471 | 67.647 1 |
| 6 | 1.40 | 1.69 | 5.80 | 1.25 | 17.00 | 1.55 | 12.80** | 1.58 | 21.40 | 8.60 | 0.401 869 | 40.186 9 |
Group* Expected Observed
Mean 6.6 3.23
Standard deviation 1.476 48 1.585 72
Standard error ± 0.660 3 ± 0.709 15
n 5 5
*P < 0.01 (5 donors)