Table 1.

Dose fractionation and BED of prostate HDR brachytherapy as monotherapy

					HDR physical dose				BED (Gy)			EQD2Gy (Gy)
Author [ref.]	Institution	Country	Start (year)	Publication (year)	Dose/ fraction	No. of fractions	Total dose		α/β = 1.5 Gy	α/β = 3.0 Gy		α/β = 1.5 Gy	α/β = 3.0 Gy
Yoshioka [5, submitted for publication, 19–21]	Osaka University	Japan	1995	2000	6 Gy	8	48 Gy		240	144		103	86
			1996	2011	6 Gy	9	54 Gy		270	162		116	97
			2005	in submission	6.5 Gy	7	45.5 Gy		243	144		104	86
Demanes [12]	California Endocurietherapy	USA	1996	2011	7 Gy	6 (2 implants)	42 Gy		238	140		102	84
Martinez [6, 18, 22]	William Beaumont Hospital	USA	1999	2010	9.5 Gy	4	38 Gy		279	158		119	95
			2005	2012	12 Gy	2	24 Gy		216	120		93	72
					13.5 Gy	2	27 Gy		270	149		116	89
Rogers [11]	Salt Lake City	USA	2001	2012	6.5 Gy	6 (2 implants)	39 Gy		208	124		89	74
Zamboglou [7, 10]	Klinikum Offenbach	Germany	2002	2004	9.5 Gy	4	38 Gy		279	158		119	95
				2013	9.5 Gy	4 (2 implants)	38 Gy		279	158		119	95
					11.5 Gy	3 (3 implants)	34.5 Gy		299	167		128	100
Hoskin [8, 9]	Mount Vernon Hospital	UK	2003	2008	8.5 Gy	4	34 Gy		227	130		97	78
					9 Gy	4	36 Gy		252	144		108	86
					10.5 Gy	3	31.5 Gy		252	142		108	85
				2012	13 Gy	2	26 Gy		251	139		108	83
Ghadjar [13]	University of Bern	Switzerland	2003	2009	9.5 Gy	4	38 Gy		279	158		119	95
Barkati [14]	Melbourne	Australia	2003	2012	10 Gy	3	30 Gy		230	130		99	78
					10.5 Gy	3	31.5 Gy		252	142		108	85
					11 Gy	3	33 Gy		275	154		118	92
					11.5 Gy	3	34.5 Gy		299	167		128	100
Yoshida [15]	Osaka National Hospital	Japan	2004	2010	7 Gy	7	49 Gy		278	163		119	98
					6 Gy	9	54 Gy		270	162		116	97
					9.5 Gy	4	38 Gy		279	158		119	95
Komiya [16]	University of Toyama	Japan	2007	2013	6.5 Gy	7	45.5 Gy		243	144		104	86
Prada [17]	Asturias	Spain	2008	2012	19 Gy	1	19 Gy		260	139		111	84

BED = biologically effective dose, HDR = high-dose-rate, EQD_2Gy = biologically equivalent dose in 2-Gy fractions.