Fig. 6.
Sensitization of pancreatic cancer cells, (1) Colo-357, (2) L3.6pl and (3) BxPC-3 to B-DIM (20 μmol/L) and (A) Gemcitabine (Gz) or (B) cisplatin-induced apoptosis as determined by ELISA after 96 h pretreatment with B-DIM (20 μmol/L) alone or a combination of B-DIM (48 h) followed by gemcitabine/cisplatin for 48 h. Increased apoptotic response was evident in combination treatment group of the cells relative to untreated control or individual treatment groups. Each point represents average of 4–5 independent experiments.