. 2013 Oct;4(5):320–334. doi: 10.1177/2040620713490316

Table 5.

Clinical trials with ECP in acute GVHD.

Study	ECP regimen	Number of patients	Skin	GI	Liver	OS (%)
Greinix et al. [1998]	Twice every 2 weeks for 3 months, then twice monthly	6	OR=100%		OR=100%	100
Greinix et al. [1998]	Twice every 2 weeks for 3 months, then twice monthly	6	CR=67%		CR=100%	100
Greinix et al. [2000]	Twice every 1–2 weeks to response then twice every 2–4 weeks	21	OR=81%	OR=None	OR=67%	57
Greinix et al. [2000]		21	CR=62%	OR=None	CR=67%	57
Salvaneschi et al. [2001]^*	Thrice weekly to response then twice every 2 weeks for 3 months	9	OR=89%	OR=60%	OR=20%	67
Salvaneschi et al. [2001]^*		9	CR=67%	CR=60%	CR=20%	67
Messina et al. [2003]^*	Twice weekly for 1 month, then twice every 2 weeks for 2 months, then twice monthly for 3 months	33	OR=82%	OR=75%	OR=60%	58
Messina et al. [2003]^*		33	CR=76%	CR=75%	CR=60%	58
Perotti et al. [2010]^*	Twice–thrice weekly to response then twice weekly for 1 week then twice every 2 weeks then twice monthly	50	OR=83%	OR=73%	OR=67%	44
Greinix et al. [2006]	Twice weekly to response then twice every 2–4 weeks	59	CR=82%	CR=60%	CR=61%	47
Perfetti et al. [2008]	Twice weekly for 1 months, then twice every 2 weeks for 2 months, then twice monthly until CR or stabilization	23	CR=66%	CR=40%	CR=27%	48

CR, complete response; ECP, extracorporeal photopheresis; GI, gastrointestinal; GVHD, graft-versus-host disease; OR, overall response (complete + partial response); OS, overall survival.

Study involving pediatric patients.