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. Author manuscript; available in PMC: 2013 Sep 7.
Published in final edited form as: Crit Rev Biomed Eng. 2012;40(5):363–408. doi: 10.1615/critrevbiomedeng.v40.i5.10

FIGURE 3.

FIGURE 3

Illustration of a three-step biomechanical paradigm in BTE. In the first step, upon implantation, it is critical that the mechanical properties of the BTE scaffold should closely match that of the surrounding host bone tissue and loading conditions to reduce the stress-shielding effect. The second step involves interface biomechanics, and should allow for interface scaffold-bone mechanotransduction for enhanced osteointegration of the scaffold. Lastly, as the scaffold degrades, ingrowing bone tissue will begin to support the mechanical load of BTE scaffold. Adapted from Pioletti (97).