Table 3.
Prevalence of Depressive and Anxiety Disorders by TPH Gene Polymorphisms
| Genotype | ||||
|---|---|---|---|---|
|
| ||||
| TPH1 SNP1 (rs4537731) | AA (n = 76) | AG (n = 96) | GG (n = 27) | p-valuea |
| Depressive disorders | ||||
| Any type of depressive episodes or dysthymia, n (%) | 33 (43%) | 39 (41%) | 11 (41%) | 0.93 |
| Recurrent moderate-to-severe depressive episode, n (%) | 14 (18%) | 23 (24%) | 4 (15%) | 0.49 |
| Suicide ideation, n (%) | 22 (31%) | 27 (29%) | 4 (15%) | 0.31 |
| Anxiety disorders | ||||
| Any anxiety disorder, n (%) | 35 (46%) | 38 (40%) | 9 (33%) | 0.47 |
| GAD, n (%) | 13 (18%) | 13 (14%) | 2 (8%) | 0.44 |
| PTSD, n (%) | 8 (11%) | 17 (18%) | 4 (15%) | 0.43 |
|
| ||||
| TPH1 SNP2 (rs684302) | CC (n = 63) | CT (n = 97) | TT (n = 40) | |
|
| ||||
| Depressive disorders | ||||
| Any type of depressive episodes or dysthymia, n (%) | 27 (43%) | 36 (37%) | 20 (50%) | 0.37 |
| Recurrent moderate-to-severe depressive episode, n (%) | 14 (22%) | 16 (17%) | 11 (28%) | 0.32 |
| Suicide ideation, n (%) | 19 (32%) | 21 (22%) | 13 (34%) | 0.27 |
| Anxiety disorders | ||||
| Any anxiety disorder, n (%) | 27 (43%) | 37 (38%) | 18 (45%) | 0.71 |
| GAD, n (%) | 8 (13%) | 15 (16%) | 5 (13%) | 0.85 |
| PTSD, n (%) | 9 (15%) | 14 (15%) | 6 (15%) | 1.00 |
|
| ||||
| TPH1 SNP3 (rs211105) | TT (n = 125) | GT (n=66) | GG (n=9) | |
|
| ||||
| Depressive disorders | ||||
| Any type of depressive episodes or dysthymia, n (%) | 56 (45%) | 24 (36%) | 3 (33%) | 0.45 |
| Recurrent moderate-to-severe depressive episode, n (%) | 27 (22%) | 13 (20%) | 1 (11%) | 0.74 |
| Suicide ideation, n (%) | 32 (26%) | 19 (30%) | 2 (25%) | 0.86 |
| Anxiety disorders | ||||
| Any anxiety disorder, n (%) | 55 (44%) | 25 (38%) | 2 (22%) | 0.36 |
| GAD, n (%) | 20 (16%) | 8 (13%) | 0 (0%) | 0.39 |
| PTSD, n (%) | 16 (13%) | 11 (18%) | 2 (25%) | 0.53 |
|
| ||||
| TPH1 SNP4 (rs1800532) | CC (n = 72) | AC (n = 89) | AA (n = 39) | p-valuea |
|
| ||||
| Depressive disorders | ||||
| Any type of depressive episodes or dysthymia, n (%) | 29 (40%) | 34 (38%) | 20 (51%) | 0.37 |
| Recurrent moderate-to-severe depressive episode, n (%) | 15 (21%) | 15 (17%) | 11 (28%) | 0.34 |
| Suicide ideation, n (%) | 21 (30%) | 19 (22%) | 13 (35%) | 0.27 |
| Anxiety disorders | ||||
| Any anxiety disorder, n (%) | 30 (42%) | 35 (40%) | 17 (44%) | 0.89 |
| GAD, n (%) | 10 (15%) | 13 (15%) | 5 (13%) | 0.97 |
| PTSD, n (%) | 11 (16%) | 12 (14%) | 6 (16%) | 0.90 |
|
| ||||
| TPH2 SNP5 (rs4570625) | GG (n = 131) | GT (n = 62) | TT (n = 6) | |
|
| ||||
| Depressive disorders | ||||
| Any type of depressive episodes or dysthymia, n (%) | 60 (46%) | 22 (36%) | 1 (17%) | 0.18 |
| Recurrent moderate-to-severe depressive episode, n (%) | 30 (23%) | 10 (16%) | 1 (17%) | 0.54 |
| Suicide ideation, n (%) | 36 (29%) | 15 (25%) | 2 (33%) | 0.86 |
| Anxiety disorders | ||||
| Any anxiety disorder, n (%) | 55 (42%) | 24 (39%) | 3 (50%) | 0.83 |
| GAD, n (%) | 19 (15%) | 8 (14%) | 1 (17%) | 0.96 |
| PTSD, n (%) | 19 (15%) | 9 (15%) | 1 (17%) | 1.00 |
IBS, irritable bowel disorder; GAD, general anxiety disorder; PTSD, posttraumatic stress disorder
a
p value based on Chi-square test.