Table 5.
Association between TPH gene polymorphisms and IBS-specific QOL. Higher scores indicate better QOL.
| IBS-QOL Mean (sd) |
|||||
|---|---|---|---|---|---|
|
| |||||
| TPH1 SNP1 (rs4537731) | AA (n = 71) | AG (n = 91) | GG (n = 27) | P valuea | P valueb |
| QOL-total | 71.7 (13.5) | 67.8 (14.6) | 70.5 (12.6) | 0.219 | 0.456 |
| Emotional | 58.5 (20.3) | 54.4 (20.7) | 62.3 (18.3) | 0.124 | 0.228 |
| Mental Health | 82.2 (16.0) | 79.6 (16.2) | 83.5 (13.1) | 0.403 | 0.609 |
| Energy | 72.4 (21.4) | 64.6 (22.1) | 66.7 (20.8) | 0.075 | 0.113 |
| Physical functioning | 83.0 (14.9) | 77.2 (20.5) | 79.2 (18.9) | 0.158 | 0.213 |
| Social role | 67.1 (22.7) | 61.9 (23.5) | 63.2 (25.6) | 0.435 | 0.851 |
| TPH1 SNP2 (rs684302) | CC (n = 59) | CT (n = 94) | TT (n = 37) | ||
|
| |||||
| QOL-total | 67.9 (13.3) | 69.5 (15.0) | 73.5 (11.5) | 0.533 | 0.086 |
| Emotional | 57.5 (19.7) | 55.7 (20.4) | 59.8 (21.3) | 0.515 | 0.694 |
| Mental Health | 80.5 (14.2) | 79.6 (17.0) | 86.5 (13.9) | 0.070 | 0.092 |
| Energy | 63.5 (20.2) | 66.5 (22.6) | 78.0 (19.9) | 0.005 | 0.002 |
| Physical functioning | 77.2 (18.2) | 80.1 (19.4) | 82.6 (16.3) | 0.434 | 0.389 |
| Social role | 60.2 (25.8) | 64.4 (23.1) | 69.3 (19.3) | 0.226 | 0.353 |
| TPH1 SNP3 (rs211105) | TT (n = 119) | GT (n = 62) | GG (n = 9) | ||
|
| |||||
| QOL-total | 71.4 (13.5) | 66.9 (14.6) | 67.2 (12.8) | 0.098 | 0.058 |
| Emotional | 58.9 (20.4) | 54.0 (20.0) | 54.9 (20.9) | 0.220 | 0.196 |
| Mental Health | 82.7 (15.2) | 78.6 (16.6) | 79.4 (15.1) | 0.223 | 0.358 |
| Energy | 71.6 (21.5) | 62.1 (21.0) | 58.3 (22.5) | 0.008 | 0.002 |
| Physical functioning | 81.0 (17.1) | 77.8 (20.5) | 75.0 (20.4) | 0.465 | 0.496 |
| Social role | 66.4 (22.4) | 61.0 (24.3) | 54.2 (28.5) | 0.183 | 0.109 |
| TPH1 SNP4 (rs1800532) | CC (n = 68) | AC (n = 86) | AA (n = 36) | ||
|
| |||||
| QOL-total | 66.9 (13.7) | 70.5 (14.7) | 73.5 (11.6) | 0.055 | 0.042 |
| Emotional | 55.0 (21.1) | 57.5 (19.2) | 60.1 (21.5) | 0.472 | 0.461 |
| Mental Health | 78.0 (16.1) | 81.5 (15.5) | 86.7 (14.0) | 0.027 | 0.026 |
| Energy | 62.9 (20.6) | 67.3 (22.3) | 78.8 (19.6) | 0.002 | <0.001 |
| Physical functioning | 77.4 (17.9) | 80.3 (19.6) | 82.3 (16.5) | 0.457 | 0.510 |
| Social role | 59.8 (25.5) | 65.5 (23.1) | 68.6 (19.1) | 0.176 | 0.381 |
| TPH2 SNP5 (rs4570625) | GG (n = 127) | GT (n = 57) | TT (n = 5) | ||
|
| |||||
| QOL-total | 68.9 (14.6) | 71.6 (11.6) | 69.5 (21.1) | 0.464 | 0.519 |
| Emotional | 55.5 (19.6) | 60.2 (21.6) | 57.5 (24.8) | 0.424 | 0.390 |
| Mental Health | 81.0 (15.5) | 81.8 (16.5) | 78.0 (15.7) | 0.852 | 0.990 |
| Energy | 66.6 (23.4) | 71.1 (17.1) | 60.0 (28.5) | 0.324 | 0.346 |
| Physical functioning | 77.7 (19.8) | 83.6 (14.5) | 83.3 (21.2) | 0.140 | 0.107 |
| Social role | 63.4 (23.9) | 65.7 (21.9) | 60.0 (35.0) | 0.773 | 0.897 |
a
p value based on one way analysis of variance
b
p value based on one way analysis of variance with controlling for GSI and GI symptoms (abdominal pain, diarrhea, constipation, bloating, intestinal gas)