. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: J Child Psychol Psychiatry. 2013 Jul 3;54(10):1074–1085. doi: 10.1111/jcpp.12109

Table 2.

Risk alleles contributing to the final latent genetic variable in the Final Model

Chromosome Location	Gene	Risk SNP (Hets/Hom/#Typed)	Univariate Analysis (p-value)	Final Model (coefficient)	Final Model (p-value)	Haplotyping Results
4q31.23	NR3C2	rs3843413 22/94/121	0.065	−0.524	0.007	L-M^*
11q14.3	GRM5^†	rs1874946 100/35/237	0.015	1.000	<0.0001	L-T^**
11q23.2	NCAM1	rs1545086 127/40/240	0.052	0.644	0.004	L-M^/L-T^*
11q23.2	DRD2^†	rs4587762 107/42/237	0.022	0.764	0.004	L-M^*/M-T^/L-T^**
12q14.2	AVPR1A^†	rs10877970 63/9/236	0.051	0.699	0.003	M-T^*
15q13.3	CHRNA7	rs1514246 105/26/236	0.076	0.515	0.005	L-M^/M-T^/L-T^**
15q21.1	SQRDL	rs626808 75/7/240	0.135	0.537	0.006	M-T^*
16p13.2	GRIN2A^†	rs8047589 99/103/238	0.060	0.592	0.004	L-M^/M-T^/L-T^*

^†

Loci included in the Initial Model of the Latent genetic variable (see text).

See text for the full names of the genes and Supplemental Table 1 for a complete presentation of the information concerning each risk single nucleotide polymorphism (SNP). The reference SNP ID number (rs#) is provided as is the number of heterozygotes (HETs), the number of homozygotes (HOMs), as well as the total number of individuals typed for the identified risk alleles. L = Low; M = Middle; and T = Top refer to the low, middle and top scores on the latent antisocial variable (see Figure 2). The coefficient for NR3C2 has a negative sign indicating that the more frequently occurring genotype C is associated with an increased risk of antisocial behavior when considered in combination with the other genes.

p <0.05;

^**

p <0.01;

^***

p <0.001