Table 1.
Effects of FA-induced acute kidney injury on animals maintained on a 3 standard phosphate diet.
| T=0 | T=24 hours vehicle |
T=24 hours FA |
P value T=24 vehicle vs FA |
|
|---|---|---|---|---|
| BUN (mg/dL) | 21±1 (N=13) |
19±2 (N=6) |
118±9 (N=8) |
<0.01 |
| Phosphate (mg/dL) |
6.7±0.2 (N=21) |
6.4±0.3 (N=11) |
11.2±1.4 (N=12) |
<0.05 |
| Calcium (mg/dL) |
8.1±0.3 (N=8) |
8.4±0.5 (N=4) |
8.2±0.8 (N=4) |
NS |
| cFGF23 (pg/mL) |
245±22 (N=17) |
307±19 (N=13) |
4500±562 (N=16) |
<0.01 |
|
iFGF23
(pg/mL) |
136±6
(N=9) |
121±7
(N=5) |
2651±510
(N=5) |
<0.01 |
| PTH (pg/mL) | 127±33 (N=10) |
85±38 (N=7) |
1359±320 (N=7) |
<0.05 |
Shown are mean±SEM (number of animals). Means for BUN, phosphate, 7 cFGF23 and PTH are from two or more independent experiments. P value 8 shown is for vehicle-injected versus FA-injected animals at 24 hours post9 injection.
FA = folic acid; BUN = blood urea nitrogen; PTH = parathyroid hormone