Table 3.
Effects of AKI on genetically 1 modified animals
| Experimental condition |
Parameter | T=0 | T=24 hours AKI |
P value T=24 vs t=0 |
|---|---|---|---|---|
| PPR-cKO | BUN (mg/dL) | 14±2 (N=6) |
135±8 (N=7) |
<0.01 |
| Phosphate (mg/dL) |
5.49±0.5 (N=7) |
21.1±1.9 (N=7) |
<0.01 | |
| cFGF23 (pg/mL) |
324±28 (N=7) |
5013±626 (N=7) |
<.01 | |
| VDR-null | BUN (mg/dL) | 20.2±4.3 (N=3) |
175±9.2 (N=4) |
<0.01 |
| Phosphate (mg/dL) |
6.2±0.7 (N=3) |
16.6±2.8 (N=4) |
<0.05 | |
| cFGF23 (pg/mL) |
584±135 (N=4) |
5912±149 (N=4) |
<0.01 | |
| PTH-null | BUN (mg/dL) | 27.2±12.2 (N=5) |
154±69 (N=5) |
<0.01 |
| Phosphate (mg/dL) |
NA | 25±11.2 (N=4) |
NA | |
| cFGF23 (pg/mL) |
185±30 (N=8) |
1860±489 (N=5) |
<0.01 |
Shown are mean±SEM (number of animals). P value shown is for baseline (t=0) 4 versus 24 hours post-injection in FA-injected animals. NA=not available. 5 FA = folic acid; BUN = blood urea nitrogen