Table 4.
Effects of AKI on animals on low and normal 1 phosphate diets
| Experimental condition |
Parameter | T=0 | T=24 hours AKI |
P value T=0 vs. T=24 |
|---|---|---|---|---|
| Control phosphate diet |
BUN (mg/dL) | 26±1 (N=4) |
117±13 (N=4) |
<0.01 |
| Phosphate (mg/dL) |
6.2±0.3 (N=9) |
13.5±1.3 (N=9) |
<0.01 | |
| cFGF23 (pg/mL) |
226±16 (N=9) |
4530±417 (N=9) |
<0.01 | |
| Low phosphate diet |
BUN (mg/dL) | 23±2 (N=6) |
98±11 (N=9) |
<0.01 |
| Phosphate (mg/dL) |
4.0±0.28* (N=12) |
7.6±0.83* (N=14) |
<0.01 | |
| cFGF23 (pg/mL) |
90±13* (N=13) |
2682±296* (N=14) |
<0.01 |
Shown are mean±SEM (number of animals). Low phosphate results represent 3 4 independent experiments; control phosphate 2 experiments. Diets have 5 controlled protein source and are otherwise equivalent except for the phosphorus 6 levels of 0.4% (control) or 0.02% (low). P value shown is for baseline (t=0) 7 versus 24 hours post-injection in FA-injected animals.
*
=p<0.01 comparing 8 between-group differences between mice on a control vs. low phosphate diet. A 9 = folic acid; BUN = blood urea nitrogen