Table 2.
Minimally Adjusted Linear Regression Models Showing Associations of Ascending Aortic Luminal Diameter with Cardiovascular Disease Risk Factors in 3573 MESA Participants, 2000–02
| Variable | Regression Coefficient (mm) |
95% CI | p |
|---|---|---|---|
| BASELINE MODEL | |||
| Age ( per SD of 10 yrs) 1 | 1.2 | 1.1–1.3 | <0.001 |
| Gender 2 | 1.9 | 1.6–2.1 | <0.001 |
| Body Surface Area (per SD of 0.23m2)3 | 1.0 | 0.9–1.1 | <0.001 |
| BASELINE MODEL+ ONE VARIABLE | |||
| Traditional Risk Factors | |||
| Race | |||
| …Caucasian | Reference | Reference | |
| Chinese American | 1.7 | 1.3–2.1 | <0.001 |
| African American | −0.2 | −0.4-0.1 | 0.20 |
| Hispanic | 0.1 | −0.2–0.4 | 0.57 |
| Systolic BP (per SD of 21 mmHg)4 | 0.3 | 0.2–0.5 | <0.001 |
| Diastolic BP (per SD of 10 mmHg)4 | 0.7 | 0.6–0.8 | <0.001 |
| Mean BP (per SD of 13 mmHg) 4 | 0.6 | 0.4–0.7 | <0.001 |
| Pulse Pressure (per SD of 17 mmHg) 4 | −0.1 | −0.3-0.0 | 0.07 |
| Hypertension (yes) | 0.9 | 0.7–1.2 | <0.001 |
| Cigarette Smoking (yes) | −0.2 | −0.4-0.0 | 0.07 |
| Diabetes (yes) | −0.4 | −0.8-−0.1 | 0.02 |
| Total Cholesterol (per SD of 36 mg/dl)5 | −0.1 | −0.2-0.0 | 0.08 |
| HDL (per SD of 15 mg/dl)5 | −0.02 | −0.1-0.1 | 0.74 |
| LDL ( per SD of 32 mg/dl)5 | −0.1 | −0.2-0.0 | 0.18 |
| Triglycerides ( per SD of 89 mg/dl)5 | −0.04 | −0.2-0.1 | 0.43 |
| Measures of Subclinical Atherosclerosis | |||
| Coronary Calcium Score (present) | 0.3 | 0.1–0.5 | 0.015 |
| Log CAC (per SD of 2.52) | 0.21 | 0.1–0.4 | 0.001 |
| Maximum CCA IMT (per SD of 0.19mm) | 0.1 | 0.0–0.3 | 0.06 |
| Maximum ICA IMT (per SD of 0.60mm) | −0.1 | −0.2-0.1 | 0.44 |
| Systemic Inflammatory Markers | |||
| IL-6 (per SD of 1.22pg/ml) | −0.03 | −0.2-0.1 | 0.59 |
| CRP (per SD of 6 mg/l) | −0.1 | −0.2-0.0 | 0.17 |
CI: Confidence Interval, BP: blood pressure, CAC: coronary artery calcium score, CCA IMT: common carotid artery intima media thickness, ICA IMT: Internal carotid artery intima media thickness.
All models (except for age, gender and, body surface area) were adjusted for age, gender, body surface area.
1
Adjusted for gender, body surface area
2
Adjusted for age, body surface area
3
Adjusted for age and gender
4
Adjusted for age, gender, body surface area, hypertension medication use
5
Adjusted for age, gender, body surface area, lipid lowering medication use.