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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Clin Cancer Res. 2013 Jul 15;19(17):4717–4727. doi: 10.1158/1078-0432.CCR-12-3891

Table 1.

Cytotoxicity of D2C7 (EGFRwt and EGFRvIII), TP-38 (EGFRwt) and MR1-1 (EGFRvIII) immunotoxins toward EGFRwt/EGFRvIII transfected cell lines*

Cell line D2C7
IC50 ng/ml		 TP-38
IC50 ng/ml		 MR1-1
IC50 ng/ml
NR6W 0.467 ± 0.18 4.6 ± 2.2 74.7 ± 17.9
NR6M 0.253 ± 0.04 101.7 ± 14.4 0.413 ± 0.03
*

Cytotoxicity data are given as an IC50 value, the concentration of immunotoxin that causes a 50% inhibition of protein synthesis after a 20-h incubation with immunotoxin. All the assays were performed in triplicate for each cell line. Results are presented as mean ± standard deviation where n ≥ 2.