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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Pediatr Res. 2013 Jun 19;74(3):259–265. doi: 10.1038/pr.2013.103

Fig. 5.

Fig. 5

Multiple signaling pathways are involved in mucous cell differentiation by TNFα+RA+Math1. All the inhibitors used in this study, except JAK1, significantly inhibited the mucous granule formation induced by TNFα+RA+Math1(A, white bar, TMath1; grey bar, RMath1; black bar, TRMath1). JAK1 did not affect the mucous cell differentiation triggered by TNFα+RA+Math1 whereas SB431542 did not affect the mucous cell differentiation triggered by TNFα+Math1 (arrow head) but toxic to TNFα+RA+Math1 treated cells (black arrow). Immunohitochemistry demonstrated that PD98059, SB203580, LY294002, AG1478, and SP600125 inhibited the expression of TFF3 in TNFα+RA+Math1 treated cells (B). bar=5 µm. *p<0.05 (n=6)