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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Neurochem. 2013 Jun 12;126(6):705–714. doi: 10.1111/jnc.12312

Figure 2. Intracellular mechanisms of leptin action during single-cell recordings of PPN neuron.

Figure 2

A) Percentage of block of whole-cell patch clamp recorded sodium current (INa,left graph) and h-current (IH, right graph) by leptin alone (black columns) compared to leptin + triple antagonist (TA 100 nM, white columns). B) Percentage of sodium current block (left) and h-current block (right) by leptin alone (black columns) compared to leptin + intracellular GDPβ (white columns). C) Percentage of sodium current block (left) and h-current block (right) by leptin alone (black columns) compared to leptin + GTPγS (white columns). Vertical bars represent Mean ± S.E.M. Cell numbers shown in parentheses inside bars. All recordings were performed in the presence of gabazine (10 μM) and strychnine (10 μM).