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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2013 May 29;22(8):1428–1445. doi: 10.1158/1055-9965.EPI-13-0185

Table 5.

Odds Ratios and Relative Excess Risk Due to Interaction Estimates for Joint Effects of Single Nucleotide Polymorphisms (SNPs) in Nucleotide Excision Repair (NER) Genes and Ever Cigarette Smoking on Head and Neck Cancer Risk Using Conventional Logistic Regression, the Carolina Head and Neck Cancer Epidemiology (CHANCE) Study, Whites

Coded Allele Cases/Controls Na OR (95% I)b
Gene SNP Referent (A) Variant (B) Never Cigarette, Referent SNP Never Cigarette, Variant SNP Ever Cigarette, Referent SNP Ever Cigarette, Variant SNP Never Cigarette, Variant SNP Ever Cigarette, Referent SNP Ever Cigarette, Variant SNP RERI (95% CI)c
ERCC3 (XPB) rs4150496 G A 70 154 79 255 331 238 441 427 0.66 (0.44, 0.98) 1.83 (1.27, 2.64) 1.40 (0.99, 1.98) -0.08 (-0.63, 0.46)
rs1011019 C T 66 201 84 208 396 347 376 318 1.26 (0.85, 1.87) 2.18 (1.54, 3.08) 2.28 (1.61, 3.23) -0.16 (-0.86, 0.54)
rs4150434 G A 89 264 61 145 459 406 313 259 1.20 (0.80, 1.80) 2.13 (1.56, 2.89) 2.09 (1.51, 2.90) -0.24 (-0.94, 0.45)
rs4150416 T G 56 176 93 233 354 305 416 360 1.27 (0.84, 1.90) 2.27 (1.57, 3.30) 2.27 (1.57, 3.27) -0.27 (-1.01, 0.46)
rs4150407 A G 55 129 95 280 263 182 509 483 0.77 (0.51, 1.16) 2.00 (1.33, 3.00) 1.53 (1.05, 2.21) -0.24 (-0.90, 0.41)
rs4150403 G A 118 338 32 71 618 566 154 99 1.26 (0.77, 2.06) 1.95 (1.49, 2.56) 2.60 (1.80, 3.74) 0.39 (-0.57, 1.34)
rs4150402 G A 66 201 84 208 396 347 376 317 1.26 (0.85, 1.87) 2.19 (1.55, 3.09) 2.29 (1.62, 3.26) -0.15 (-0.85, 0.55)
XPC rs2228001 A C 56 135 94 274 281 240 490 425 0.86 (0.57, 1.29) 1.91 (1.29, 2.83) 1.70 (1.17, 2.48) -0.06 (-0.66, 0.54)
rs3731143 T C 135 361 15 48 683 596 89 69 0.90 (0.48, 1.70) 1.88 (1.45, 2.44) 2.51 (1.66, 3.82) 0.73 (-0.33, 1.80)
rs2228000 C T 91 222 59 187 433 376 337 288 0.77 (0.51, 1.14) 1.74 (1.27, 2.39) 1.78 (1.28, 2.47) 0.27 (-0.23, 0.78)
rs3731124 A C 81 228 69 181 440 371 332 294 1.10 (0.74, 1.64) 2.11 (1.53, 2.90) 1.98 (1.42, 2.76) -0.23 (-0.89, 0.43)
rs13099160 A G 127 366 23 43 687 596 85 69 1.60 (0.90, 2.83) 2.07 (1.59, 2.69) 2.24 (1.47, 3.43) -0.43 (-1.65, 0.80)
rs3731093 T C 120 350 27 56 656 569 111 90 1.52 (0.89, 2.58) 2.10 (1.60, 2.75) 2.47 (1.68, 3.64) -0.15 (-1.26, 0.96)
rs3731089 G A 121 350 29 59 657 569 115 96 1.53 (0.92, 2.57) 2.07 (1.58, 2.71) 2.35 (1.61, 3.44) -0.25 (-1.32, 0.82)
rs2733537 A G 70 175 80 234 346 305 426 360 0.88 (0.59, 1.31) 1.75 (1.23, 2.50) 1.91 (1.35, 2.70) 0.28 (-0.25, 0.81)
rs3731068 C A 99 275 51 134 525 457 247 208 1.03 (0.68, 1.56) 1.97 (1.47, 2.65) 2.01 (1.44, 2.79) 0.01 (-0.65, 0.66)
rs2607755 T C 39 110 111 299 203 174 569 491 1.11 (0.71, 1.73) 2.12 (1.35, 3.34) 2.12 (1.39, 3.22) -0.11 (-0.86, 0.63)
rs1902658 G A 37 107 113 302 198 173 573 492 1.12 (0.71, 1.76) 2.10 (1.32, 3.33) 2.15 (1.40, 3.29) -0.07 (-0.81, 0.67)
ERCC8 rs3117 T C 60 144 90 265 277 253 495 412 0.81 (0.54, 1.22) 1.70 (1.16, 2.49) 1.75 (1.22, 2.51) 0.23 (-0.28, 0.75)
CDK7 rs2972388 A G 42 122 108 287 224 213 548 452 1.06 (0.69, 1.63) 1.81 (1.17, 2.79) 2.16 (1.45, 3.23) 0.29 (-0.31, 0.89)
XPA rs3176757 C T 98 268 52 141 511 442 261 223 1.03 (0.68, 1.56) 1.94 (1.44, 2.62) 2.08 (1.50, 2.89) 0.11 (-0.53, 0.75)
rs3176748 A G 74 185 76 224 366 325 406 340 0.84 (0.57, 1.25) 1.76 (1.25, 2.48) 1.82 (1.30, 2.57) 0.22 (-0.30, 0.74)
rs2808667 C T 133 352 17 57 681 598 89 67 0.87 (0.47, 1.60) 1.86 (1.43, 2.42) 2.44 (1.61, 3.71) 0.71 (-0.31, 1.73)
rs2805835 G C 119 328 31 81 608 520 164 145 1.12 (0.69, 1.82) 2.03 (1.54, 2.68) 1.95 (1.38, 2.76) -0.20 (-0.98, 0.58)
rs3176689 A T 94 279 56 130 528 449 244 216 1.14 (0.76, 1.72) 2.15 (1.60, 2.90) 1.88 (1.34, 2.63) -0.41 (-1.12, 0.29)
rs3176683 T C 134 353 16 56 684 591 88 74 0.76 (0.41, 1.40) 1.88 (1.45, 2.45) 2.05 (1.35, 3.10) 0.41 (-0.46, 1.28)
rs3176658 C T 114 297 36 112 585 495 187 170 0.85 (0.54, 1.35) 1.91 (1.44, 2.52) 1.86 (1.32, 2.60) 0.10 (-0.54, 0.73)
rs1800975 G A 72 180 75 215 348 293 390 348 0.90 (0.61, 1.35) 1.83 (1.29, 2.60) 1.86 (1.32, 2.63) 0.13 (-0.43, 0.69)
RAD23B rs1805330 C T 125 321 25 88 639 549 133 116 0.68 (0.41, 1.13) 1.85 (1.41, 2.43) 1.68 (1.16, 2.43) 0.15 (-0.49, 0.79)
rs1805329 C T 101 277 49 132 489 434 283 231 1.13 (0.74, 1.72) 2.01 (1.50, 2.70) 2.12 (1.53, 2.93) -0.02 (-0.70, 0.66)
ERCC6 rs2228529 A G 96 258 52 146 501 403 261 250 1.08 (0.71, 1.63) 2.13 (1.57, 2.89) 1.85 (1.33, 2.56) -0.37 (-1.05, 0.32)
rs2228527 A G 97 260 53 149 501 405 271 260 1.07 (0.71, 1.61) 2.13 (1.57, 2.87) 1.84 (1.33, 2.55) -0.35 (-1.03, 0.32)
rs4253132 T C 126 303 24 106 597 526 175 139 0.50 (0.30, 0.84) 1.65 (1.26, 2.18) 1.86 (1.32, 2.62) 0.70 (0.14, 1.26)
rs2228528 G A 104 287 46 122 533 459 238 206 1.05 (0.69, 1.62) 2.01 (1.50, 2.68) 1.97 (1.42, 2.74) -0.09 (-0.76, 0.58)
DDB2 (XPE) rs2029298 A G 69 195 81 214 356 283 416 382 1.22 (0.82, 1.81) 2.39 (1.69, 3.38) 2.03 (1.44, 2.86) -0.58 (-1.34, 0.18)
rs4647709 C T 123 342 27 67 643 560 129 105 1.17 (0.70, 1.96) 2.01 (1.53, 2.63) 2.12 (1.46, 3.07) -0.06 (-0.94, 0.82)
rs2291120 T C 123 296 27 113 562 516 210 149 0.59 (0.36, 0.96) 1.68 (1.28, 2.22) 1.95 (1.39, 2.74) 0.68 (0.11, 1.26)
rs1685404 G C 72 180 78 229 346 322 426 343 0.88 (0.59, 1.30) 1.66 (1.17, 2.35) 2.01 (1.43, 2.83) 0.47 (-0.03, 0.98)
rs2957873 A G 101 275 49 134 542 436 230 229 1.16 (0.76, 1.75) 2.22 (1.65, 2.98) 1.77 (1.28, 2.46) -0.60 (-1.33, 0.13)
rs326224 G A 105 288 45 121 578 473 194 192 1.18 (0.77, 1.80) 2.14 (1.61, 2.86) 1.87 (1.33, 2.62) -0.45 (-1.19, 0.29)
rs2306353 G A 109 292 41 117 587 470 185 195 1.12 (0.72, 1.74) 2.18 (1.64, 2.90) 1.66 (1.19, 2.33) -0.64 (-1.38, 0.10)
rs326222 C T 76 209 74 200 408 317 364 348 1.17 (0.79, 1.73) 2.39 (1.71, 3.34) 1.88 (1.34, 2.63) -0.68 (-1.43, 0.08)
rs901746 A G 76 210 74 199 409 318 363 347 1.19 (0.80, 1.77) 2.41 (1.73, 3.37) 1.89 (1.35, 2.65) -0.71 (-1.48, 0.05)
ERCC5 (XPG) rs2296147 T C 41 114 109 291 239 189 528 474 1.00 (0.64, 1.55) 2.14 (1.38, 3.33) 1.88 (1.24, 2.83) -0.27 (-1.01, 0.48)
rs4771436 T G 97 259 53 150 466 400 306 265 0.98 (0.65, 1.48) 1.98 (1.46, 2.68) 1.92 (1.39, 2.65) -0.05 (-0.66, 0.57)
rs1047768 C T 57 142 93 267 262 235 510 429 0.84 (0.56, 1.26) 1.71 (1.16, 2.52) 1.79 (1.24, 2.59) 0.25 (-0.28, 0.78)
rs3818356 C T 97 259 53 149 466 400 304 264 0.99 (0.66, 1.5) 1.97 (1.46, 2.67) 1.91 (1.38, 2.64) -0.06 (-0.67, 0.56)
rs4150351 A C 97 258 53 151 498 434 274 231 0.94 (0.63, 1.42) 1.92 (1.42, 2.60) 1.94 (1.40, 2.69) 0.07 (-0.53, 0.68)
rs4150355 C T 57 159 93 250 345 269 427 396 1.06 (0.70, 1.58) 2.28 (1.57, 3.32) 1.87 (1.29, 2.69) -0.47 (-1.20, 0.26)
rs4150360 T C 50 119 100 290 225 197 547 468 0.81 (0.53, 1.24) 1.70 (1.12, 2.58) 1.71 (1.16, 2.51) 0.19 (-0.36, 0.74)
rs4150383 G A 106 296 44 113 524 453 248 212 1.08 (0.70, 1.67) 2.02 (1.51, 2.70) 2.00 (1.44, 2.78) -0.10 (-0.78, 0.58)
rs4150386 A C 113 317 37 92 611 519 161 145 1.03 (0.65, 1.63) 2.03 (1.53, 2.68) 1.84 (1.29, 2.61) -0.22 (-0.95, 0.51)
rs17655 C G 89 238 61 171 466 420 306 245 0.88 (0.59, 1.32) 1.78 (1.30, 2.42) 2.04 (1.46, 2.84) 0.38 (-0.18, 0.94)
rs873601 A G 73 190 77 219 391 349 381 316 0.82 (0.55, 1.21) 1.72 (1.22, 2.41) 1.83 (1.30, 2.58) 0.30 (-0.21, 0.80)
rs4150393 A G 114 317 36 92 588 527 184 138 1.14 (0.72, 1.81) 1.94 (1.47, 2.57) 2.35 (1.67, 3.32) 0.27 (-0.53, 1.06)
rs876430 C T 73 190 77 219 392 350 380 315 0.82 (0.55, 1.21) 1.72 (1.22, 2.41) 1.83 (1.30, 2.58) 0.30 (-0.21, 0.80)
rs1051677 T C 126 331 23 78 609 527 163 138 0.80 (0.47, 1.36) 1.88 (1.43, 2.46) 2.01 (1.42, 2.85) 0.34 (-0.36, 1.03)
rs1051685 A G 117 323 33 86 619 509 152 156 1.12 (0.70, 1.80) 2.10 (1.59, 2.76) 1.67 (1.17, 2.38) -0.55 (-1.31, 0.22)
ERCC4 (XPF) rs3136038 C T 51 195 99 214 351 295 421 370 1.77 (1.17, 2.66) 2.88 (1.97, 4.21) 2.67 (1.84, 3.87) -0.97 (-1.99, 0.04)
rs1799798 G A 126 331 24 78 631 570 141 95 0.80 (0.47, 1.34) 1.82 (1.39, 2.39) 2.32 (1.59, 3.40) 0.70 (-0.11, 1.52)
rs744154 C G 59 224 91 185 421 358 351 307 1.85 (1.24, 2.76) 2.81 (1.98, 3.99) 2.63 (1.84, 3.77) -1.02 (-2.02, -0.02)
rs3136085 G C 59 220 91 189 416 356 356 309 1.80 (1.21, 2.69) 2.75 (1.93, 3.92) 2.63 (1.84, 3.77) -0.92 (-1.89, 0.05)
rs3136130 G T 51 193 99 216 349 292 423 373 1.73 (1.15, 2.61) 2.85 (1.95, 4.16) 2.65 (1.83, 3.83) -0.93 (-1.93, 0.06)
rs1800067 G A 125 355 25 54 653 565 119 100 1.26 (0.73, 2.17) 2.03 (1.55, 2.64) 2.11 (1.45, 3.07) -0.18 (-1.13, 0.77)
rs3136172 A G 59 216 91 193 399 350 373 315 1.71 (1.14, 2.55) 2.63 (1.85, 3.76) 2.63 (1.84, 3.76) -0.71 (-1.63, 0.20)
RAD23A rs2974752 A G 56 180 92 216 277 244 469 401 1.43 (0.95, 2.16) 2.38 (1.63, 3.46) 2.41 (1.68, 3.44) -0.40 (-1.22, 0.42)
ERCC2 (XPD) rs13181 T G 55 155 95 252 326 282 439 381 1.06 (0.71, 1.60) 2.08 (1.42, 3.05) 1.97 (1.36, 2.85) -0.18 (-0.84, 0.49)
rs238418 C A 54 155 96 254 328 271 444 394 1.10 (0.73, 1.65) 2.21 (1.50, 3.24) 2.01 (1.38, 2.91) -0.30 (-1.00, 0.41)
rs1799787 C T 68 203 82 206 404 342 368 323 1.17 (0.79, 1.74) 2.19 (1.56, 3.09) 2.08 (1.47, 2.94) -0.29 (-0.98, 0.40)
rs3916874 G C 81 201 69 208 396 344 376 321 0.75 (0.50, 1.11) 1.69 (1.21, 2.35) 1.72 (1.23, 2.40) 0.28 (-0.20, 0.77)
rs238416 G A 62 193 88 216 307 275 464 388 1.34 (0.90, 1.99) 2.17 (1.51, 3.12) 2.40 (1.69, 3.41) -0.11 (-0.83, 0.61)
rs50872 C T 80 221 70 187 451 363 319 301 1.06 (0.71, 1.57) 2.15 (1.55, 2.97) 1.85 (1.32, 2.59) -0.36 (-1.02, 0.31)
rs50871 T G 43 89 107 320 199 169 573 495 0.66 (0.42, 1.03) 1.37 (0.86, 2.16) 1.47 (0.96, 2.23) 0.44 (-0.01, 0.89)
rs238407 A T 43 136 107 273 220 202 551 463 1.40 (0.91, 2.16) 2.36 (1.54, 3.62) 2.53 (1.71, 3.76) -0.23 (-1.05, 0.59)
rs3810366 C G 32 95 118 314 146 137 625 528 1.29 (0.80, 2.09) 2.29 (1.38, 3.77) 2.42 (1.54, 3.80) -0.16 (-1.03, 0.72)
ERCC1 rs735482 A C 117 302 33 107 571 495 201 170 0.81 (0.51, 1.30) 1.87 (1.41, 2.47) 1.90 (1.36, 2.65) 0.22 (-0.40, 0.84)
rs2336219 G A 117 302 33 107 571 495 201 170 0.81 (0.51, 1.30) 1.87 (1.41, 2.47) 1.90 (1.36, 2.65) 0.22 (-0.40, 0.84)
rs3212964 G A 118 302 32 107 574 492 198 173 0.78 (0.49, 1.24) 1.86 (1.41, 2.46) 1.84 (1.32, 2.56) 0.20 (-0.40, 0.80)
rs3212955 A G 82 229 68 180 446 378 326 286 1.10 (0.74, 1.63) 2.08 (1.51, 2.86) 2.02 (1.45, 2.81) -0.16 (-0.81, 0.49)
rs3212948 C G 60 171 90 238 322 287 450 378 1.10 (0.74, 1.64) 2.01 (1.39, 2.90) 2.14 (1.50, 3.05) 0.03 (-0.60, 0.66)
rs3212930 T C 92 248 58 161 484 409 288 256 0.99 (0.66, 1.48) 1.95 (1.43, 2.65) 1.98 (1.43, 2.75) 0.04 (-0.57, 0.65)
LIG1 rs156641 G A 56 166 94 243 314 274 458 391 1.22 (0.81, 1.82) 2.14 (1.46, 3.13) 2.27 (1.58, 3.27) -0.09 (-0.77, 0.60)
rs20580 C A 30 109 120 300 207 184 565 481 1.54 (0.95, 2.48) 2.52 (1.55, 4.12) 2.83 (1.79, 4.47) -0.23 (-1.15, 0.69)
rs20579 C T 105 305 45 104 586 521 186 144 1.34 (0.87, 2.08) 2.06 (1.55, 2.73) 2.43 (1.71, 3.45) 0.03 (-0.81, 0.87)

OR odds ratio, RERI relative excess risk due to interaction, I interval estimates

a

Referent SNP defined as heterozygote for referent (major) allele (denoted AA) and variant SNP defined as heterozygote or homozygote for the variant (minor) allele (denoted as AB and BB).

b

Odds ratios adjusted for matching factors (age and sex including pairwise interactions), education, alcohol drinking, and proportion African ancestry. 122 individuals missing alcohol drinking, and therefore dropped from models.

c

Significant associations using a dominant genetic model (p<0.05) highlighted in gray. No associations significant at Bonferroni corrected level (p<0.0006).

Interval estimates presented not corrected for multiple comparisons.