Table 6.

Odds Ratios and Relative Excess Risk Due to Interaction Estimates for Joint Effects of Single Nucleotide Polymorphisms (SNPs) in Nucleotide Excision Repair (NER) Genes and Ever Cigarette Smoking on Head and Neck Cancer Risk Using Hierarchical Logistic Regression, the Carolina Head and Neck Cancer Epidemiology (CHANCE) Study, Whites

		Coded Allele		Cases/Controls Na								OR (95% I)b
Gene	SNP	Referent (A)	Variant (B)	Never Cigarette, Referent SNP		Never Cigarette, Variant SNP		Ever Cigarette, Referent SNP		Ever Cigarette, Variant SNP		Never Cigarette, Variant SNP	Ever Cigarette, Referent SNP	Ever Cigarette, Variant SNP	RERI
ERCC3 (XPB)	rs4150496	G	A	70	154	79	255	331	238	441	427	0.66 (0.45, 0.98)	1.84 (1.28, 2.64)	1.41 (1.00, 1.99)	-0.09
	rs1011019	C	T	66	201	84	208	396	347	376	318	1.25 (0.85, 1.85)	2.17 (1.54, 3.05)	2.27 (1.60, 3.22)	-0.15
	rs4150434	G	A	89	264	61	145	459	406	313	259	1.19 (0.80, 1.77)	2.12 (1.56, 2.87)	2.09 (1.50, 2.90)	-0.23
	rs4150416	T	G	56	176	93	233	354	305	416	360	1.25 (0.84, 1.87)	2.26 (1.57, 3.26)	2.26 (1.57, 3.25)	-0.26
	rs4150407	A	G	55	129	95	280	263	182	509	483	0.77 (0.51, 1.15)	2.00 (1.34, 2.98)	1.53 (1.05, 2.21)	-0.24
	rs4150403	G	A	118	338	32	71	618	566	154	99	1.26 (0.78, 2.04)	1.96 (1.49, 2.56)	2.60 (1.80, 3.74)	0.38
	rs4150402	G	A	66	201	84	208	396	347	376	317	1.25 (0.85, 1.85)	2.18 (1.54, 3.06)	2.29 (1.61, 3.24)	-0.14
XPC	rs2228001	A	C	56	135	94	274	281	240	490	425	0.86 (0.57, 1.28)	1.91 (1.30, 2.82)	1.70 (1.17, 2.48)	-0.06
	rs3731143	T	C	135	361	15	48	683	596	89	69	0.93 (0.51, 1.70)	1.89 (1.46, 2.45)	2.50 (1.65, 3.78)	0.67
	rs2228000	C	T	91	222	59	187	433	376	337	288	0.77 (0.52, 1.15)	1.75 (1.28, 2.39)	1.78 (1.29, 2.48)	0.26
	rs3731124	A	C	81	228	69	181	440	371	332	294	1.10 (0.74, 1.62)	2.10 (1.53, 2.88)	1.98 (1.42, 2.75)	-0.22
	rs13099160	A	G	127	366	23	43	687	596	85	69	1.56 (0.90, 2.70)	2.06 (1.59, 2.68)	2.26 (1.48, 3.45)	-0.36
	rs3731093	T	C	120	350	27	56	656	569	111	90	1.50 (0.89, 2.50)	2.09 (1.60, 2.74)	2.48 (1.68, 3.65)	-0.11
	rs3731089	G	A	121	350	29	59	657	569	115	96	1.51 (0.91, 2.49)	2.06 (1.58, 2.69)	2.36 (1.61, 3.45)	-0.21
	rs2733537	A	G	70	175	80	234	346	305	426	360	0.89 (0.60, 1.31)	1.76 (1.24, 2.50)	1.92 (1.36, 2.71)	0.26
	rs3731068	C	A	99	275	51	134	525	457	247	208	1.02 (0.68, 1.54)	1.97 (1.48, 2.64)	2.01 (1.44, 2.79)	0.01
	rs2607755	T	C	39	110	111	299	203	174	569	491	1.10 (0.71, 1.71)	2.11 (1.36, 3.29)	2.11 (1.40, 3.19)	-0.10
	rs1902658	G	A	37	107	113	302	198	173	573	492	1.11 (0.71, 1.74)	2.09 (1.33, 3.29)	2.14 (1.40, 3.27)	-0.06
ERCC8	rs3117	T	C	60	144	90	265	277	253	495	412	0.82 (0.55, 1.22)	1.71 (1.18, 2.50)	1.76 (1.23, 2.52)	0.22
CDK7	rs2972388	A	G	42	122	108	287	224	213	548	452	1.06 (0.70, 1.63)	1.82 (1.19, 2.78)	2.17 (1.46, 3.23)	0.29
XPA	rs3176757	C	T	98	268	52	141	511	442	261	223	1.03 (0.69, 1.55)	1.94 (1.44, 2.61)	2.09 (1.50, 2.89)	0.11
	rs3176748	A	G	74	185	76	224	366	325	406	340	0.85 (0.57, 1.25)	1.77 (1.26, 2.49)	1.83 (1.30, 2.57)	0.21
	rs2808667	C	T	133	352	17	57	681	598	89	67	0.90 (0.50, 1.61)	1.87 (1.44, 2.43)	2.42 (1.60, 3.68)	0.65
	rs2805835	G	C	119	328	31	81	608	520	164	145	1.11 (0.69, 1.78)	2.03 (1.54, 2.67)	1.95 (1.38, 2.76)	-0.19
	rs3176689	A	T	94	279	56	130	528	449	244	216	1.13 (0.75, 1.69)	2.14 (1.59, 2.88)	1.87 (1.34, 2.62)	-0.39
	rs3176683	T	C	134	353	16	56	684	591	88	74	0.78 (0.43, 1.40)	1.89 (1.46, 2.45)	2.04 (1.35, 3.08)	0.37
	rs3176658	C	T	114	297	36	112	585	495	187	170	0.86 (0.55, 1.34)	1.91 (1.45, 2.52)	1.86 (1.32, 2.60)	0.09
	rs1800975	G	A	72	180	75	215	348	293	390	348	0.91 (0.61, 1.34)	1.84 (1.30, 2.60)	1.87 (1.32, 2.63)	0.12
RAD23B	rs1805330	C	T	125	321	25	88	639	549	133	116	0.69 (0.42, 1.14)	1.86 (1.42, 2.43)	1.68 (1.16, 2.43)	0.13
	rs1805329	C	T	101	277	49	132	489	434	283	231	1.13 (0.75, 1.70)	2.01 (1.50, 2.69)	2.12 (1.53, 2.93)	-0.02
ERCC6	rs2228529	A	G	96	258	52	146	501	403	261	250	1.07 (0.71, 1.61)	2.12 (1.57, 2.87)	1.84 (1.33, 2.56)	-0.35
	rs2228527	A	G	97	260	53	149	501	405	271	260	1.06 (0.71, 1.58)	2.12 (1.57, 2.86)	1.84 (1.33, 2.54)	-0.34
	rs4253132	T	C	126	303	24	106	597	526	175	139	0.53 (0.32, 0.86)	1.67 (1.27, 2.20)	1.86 (1.32, 2.62)	0.65
	rs2228528	G	A	104	287	46	122	533	459	238	206	1.05 (0.69, 1.60)	2.01 (1.51, 2.68)	1.97 (1.42, 2.74)	-0.08
DDB2 (XPE)	rs2029298	A	G	69	195	81	214	356	283	416	382	1.20 (0.82, 1.77)	2.37 (1.68, 3.34)	2.02 (1.44, 2.84)	-0.55
	rs4647709	C	T	123	342	27	67	643	560	129	105	1.16 (0.71, 1.92)	2.00 (1.53, 2.62)	2.12 (1.46, 3.07)	-0.05
	rs2291120	T	C	123	296	27	113	562	516	210	149	0.61 (0.38, 0.98)	1.70 (1.29, 2.24)	1.95 (1.39, 2.74)	0.64
	rs1685404	G	C	72	180	78	229	346	322	426	343	0.89 (0.60, 1.31)	1.67 (1.19, 2.36)	2.02 (1.43, 2.84)	0.46
	rs2957873	A	G	101	275	49	134	542	436	230	229	1.14 (0.76, 1.71)	2.20 (1.64, 2.95)	1.77 (1.27, 2.46)	-0.57
	rs326224	G	A	105	288	45	121	578	473	194	192	1.16 (0.76, 1.77)	2.13 (1.60, 2.84)	1.87 (1.33, 2.62)	-0.43
	rs2306353	G	A	109	292	41	117	587	470	185	195	1.10 (0.72, 1.69)	2.17 (1.64, 2.87)	1.66 (1.19, 2.33)	-0.61
	rs326222	C	T	76	209	74	200	408	317	364	348	1.15 (0.78, 1.70)	2.37 (1.70, 3.29)	1.87 (1.34, 2.62)	-0.65
	rs901746	A	G	76	210	74	199	409	318	363	347	1.17 (0.80, 1.73)	2.39 (1.72, 3.32)	1.88 (1.35, 2.63)	-0.68
ERCC5 (XPG)	rs2296147	T	C	41	114	109	291	239	189	528	474	0.99 (0.65, 1.53)	2.13 (1.38, 3.28)	1.87 (1.24, 2.81)	-0.26
	rs4771436	T	G	97	259	53	150	466	400	306	265	0.98 (0.66, 1.47)	1.98 (1.47, 2.68)	1.92 (1.39, 2.65)	-0.05
	rs1047768	C	T	57	142	93	267	262	235	510	429	0.85 (0.57, 1.26)	1.72 (1.17, 2.52)	1.80 (1.25, 2.60)	0.24
	rs3818356	C	T	97	259	53	149	466	400	304	264	0.99 (0.66, 1.48)	1.97 (1.46, 2.66)	1.91 (1.38, 2.64)	-0.06
	rs4150351	A	C	97	258	53	151	498	434	274	231	0.95 (0.63, 1.42)	1.92 (1.43, 2.59)	1.94 (1.40, 2.69)	0.07
	rs4150355	C	T	57	159	93	250	345	269	427	396	1.05 (0.70, 1.56)	2.26 (1.56, 3.27)	1.86 (1.29, 2.67)	-0.45
	rs4150360	T	C	50	119	100	290	225	197	547	468	0.82 (0.54, 1.24)	1.71 (1.14, 2.59)	1.71 (1.17, 2.52)	0.18
	rs4150383	G	A	106	296	44	113	524	453	248	212	1.08 (0.70, 1.65)	2.02 (1.51, 2.69)	2.00 (1.44, 2.78)	-0.09
	rs4150386	A	C	113	317	37	92	611	519	161	145	1.02 (0.65, 1.60)	2.02 (1.53, 2.67)	1.84 (1.29, 2.61)	-0.21
	rs17655	C	G	89	238	61	171	466	420	306	245	0.89 (0.60, 1.32)	1.78 (1.31, 2.43)	2.04 (1.46, 2.84)	0.36
	rs873601	A	G	73	190	77	219	391	349	381	316	0.83 (0.56, 1.21)	1.73 (1.24, 2.42)	1.84 (1.31, 2.58)	0.28
	rs4150393	A	G	114	317	36	92	588	527	184	138	1.15 (0.73, 1.80)	1.94 (1.47, 2.56)	2.35 (1.67, 3.32)	0.26
	rs876430	C	T	73	190	77	219	392	350	380	315	0.83 (0.56, 1.21)	1.73 (1.24, 2.41)	1.84 (1.31, 2.59)	0.29
	rs1051677	T	C	126	331	23	78	609	527	163	138	0.81 (0.49, 1.36)	1.89 (1.44, 2.47)	2.01 (1.42, 2.85)	0.31
	rs1051685	A	G	117	323	33	86	619	509	152	156	1.10 (0.70, 1.75)	2.09 (1.59, 2.74)	1.67 (1.18, 2.38)	-0.52
ERCC4 (XPF)	rs3136038	C	T	51	195	99	214	351	295	421	370	1.72 (1.16, 2.57)	2.82 (1.94, 4.10)	2.64 (1.83, 3.81)	-0.91
	rs1799798	G	A	126	331	24	78	631	570	141	95	0.82 (0.50, 1.36)	1.83 (1.40, 2.40)	2.32 (1.58, 3.39)	0.66
	rs744154	C	G	59	224	91	185	421	358	351	307	1.80 (1.22, 2.66)	2.76 (1.95, 3.90)	2.61 (1.82, 3.73)	-0.95
	rs3136085	G	C	59	220	91	189	416	356	356	309	1.76 (1.19, 2.60)	2.71 (1.91, 3.83)	2.61 (1.82, 3.73)	-0.86
	rs3136130	G	T	51	193	99	216	349	292	423	373	1.69 (1.13, 2.52)	2.79 (1.92, 4.05)	2.61 (1.81, 3.78)	-0.87
	rs1800067	G	A	125	355	25	54	653	565	119	100	1.24 (0.73, 2.11)	2.02 (1.55, 2.63)	2.11 (1.45, 3.07)	-0.15
	rs3136172	A	G	59	216	91	193	399	350	373	315	1.67 (1.13, 2.48)	2.60 (1.83, 3.68)	2.61 (1.82, 3.73)	-0.66
RAD23A	rs2974752	A	G	56	180	92	216	277	244	469	401	1.42 (0.95, 2.11)	2.35 (1.62, 3.41)	2.39 (1.67, 3.42)	-0.37
ERCC2 (XPD)	rs13181	T	G	55	155	95	252	326	282	439	381	1.06 (0.71, 1.58)	2.08 (1.43, 3.02)	1.96 (1.36, 2.84)	-0.17
	rs238418	C	A	54	155	96	254	328	271	444	394	1.09 (0.73, 1.63)	2.19 (1.50, 3.20)	2.00 (1.38, 2.89)	-0.28
	rs1799787	C	T	68	203	82	206	404	342	368	323	1.16 (0.79, 1.71)	2.18 (1.56, 3.06)	2.07 (1.47, 2.93)	-0.27
	rs3916874	G	C	81	201	69	208	396	344	376	321	0.76 (0.51, 1.11)	1.70 (1.22, 2.36)	1.73 (1.24, 2.41)	0.27
	rs238416	G	A	62	193	88	216	307	275	464	388	1.33 (0.90, 1.96)	2.16 (1.51, 3.09)	2.40 (1.69, 3.39)	-0.09
	rs50872	C	T	80	221	70	187	451	363	319	301	1.05 (0.71, 1.55)	2.14 (1.55, 2.95)	1.85 (1.32, 2.58)	-0.34
	rs50871	T	G	43	89	107	320	199	169	573	495	0.67 (0.44, 1.05)	1.40 (0.89, 2.19)	1.49 (0.98, 2.25)	0.41
	rs238407	A	T	43	136	107	273	220	202	551	463	1.39 (0.91, 2.11)	2.33 (1.53, 3.55)	2.51 (1.70, 3.72)	-0.21
	rs3810366	C	G	32	95	118	314	146	137	625	528	1.28 (0.81, 2.04)	2.26 (1.39, 3.68)	2.41 (1.54, 3.75)	-0.14
ERCC1	rs735482	A	C	117	302	33	107	571	495	201	170	0.82 (0.52, 1.30)	1.87 (1.42, 2.47)	1.90 (1.36, 2.65)	0.20
	rs2336219	G	A	117	302	33	107	571	495	201	170	0.82 (0.52, 1.30)	1.87 (1.42, 2.47)	1.90 (1.36, 2.65)	0.20
	rs3212964	G	A	118	302	32	107	574	492	198	173	0.79 (0.50, 1.24)	1.87 (1.42, 2.46)	1.84 (1.32, 2.56)	0.18
	rs3212955	A	G	82	229	68	180	446	378	326	286	1.09 (0.74, 1.61)	2.08 (1.51, 2.85)	2.02 (1.45, 2.81)	-0.15
	rs3212948	C	G	60	171	90	238	322	287	450	378	1.10 (0.74, 1.63)	2.01 (1.40, 2.88)	2.14 (1.50, 3.05)	0.03
	rs3212930	T	C	92	248	58	161	484	409	288	256	0.99 (0.67, 1.47)	1.95 (1.44, 2.64)	1.98 (1.43, 2.75)	0.04
LIG1	rs156641	G	A	56	166	94	243	314	274	458	391	1.21 (0.81, 1.80)	2.13 (1.47, 3.10)	2.26 (1.57, 3.26)	-0.08
	rs20580	C	A	30	109	120	300	207	184	565	481	1.51 (0.95, 2.41)	2.48 (1.54, 4.00)	2.80 (1.78, 4.38)	-0.20
	rs20579	C	T	105	305	45	104	586	521	186	144	1.34 (0.87, 2.05)	2.05 (1.55, 2.72)	2.43 (1.71, 3.45)	0.04

OR odds ratio, RERI relative excess risk due to interaction, I interval estimates

^aReferent SNP defined as heterozygote for referent (major) allele (denoted AA) and variant SNP defined as heterozygote or homozygote for the variant (minor) allele (denoted as AB and BB).

^bOdds ratios adjusted for matching factors (age and sex including pairwise interactions), education, alcohol drinking, and proportion African ancestry. 122 individuals missing alcohol drinking, and therefore dropped from models.

Interval estimates presented not corrected for multiple comparisons.