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Effect of olanzapine on lipid content (a) and mRNA content of mammalian Pdp1 homologues (b) in mouse 3T3-L1 cells. Vehicle (open bars) and olanzapine (50 μM; closed bars) were present in the culture medium for 24 h. Olanzapine increased lipid content (a) and HLF mRNA content (normalized to internal control mRNA) (b) (*P < 0.001 versus corresponding control; n = 6; mean ± standard error mean).
